等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
500 μg/mL in acetonitrile: water (1:1)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c3ccc(cc3)C(O)=O
InChI
1S/C19H19N3O3/c1-12-4-9-16-20-18(13-5-7-14(8-6-13)19(24)25)15(22(16)11-12)10-17(23)21(2)3/h4-9,11H,10H2,1-3H3,(H,24,25)
InChI key
FELZONDEFBLTSP-UHFFFAOYSA-N
一般描述
唑吡坦苯基-4-羧酸是唑吡坦在尿液中的主要代谢物，占进药剂量的51%。文献表明，服用单剂唑吡坦后，尿液中会有2-3天出现该代谢物。唑吡坦(Zolpidem)，商品名为安必恩(Ambien®)或思诺思(Stilnox®)，是用于短期治疗失眠的非苯二氮䓬类药物。
应用
- Pharmacokinetics in forensic contexts: A study demonstrated the simultaneous analysis of Zolpidem and its metabolites, including Zolpidem phenyl-4-carboxylic acid, in postmortem urine, which is critical for forensic toxicology (Yamaguchi et al., 2023).
- Detection in hair samples: Research developed a sensitive LC-MS/MS method for detecting picogram levels of Zolpidem and its primary metabolites, such as Zolpidem phenyl-4-carboxylic acid, in hair, offering valuable insights for forensic and clinical investigations (Kim et al., 2021).
- Advanced analytical techniques: The determination of Zolpidem phenyl-4-carboxylic acid and Zolpidem 6-carboxylic acid in hair was achieved using gas chromatography-electron ionization-tandem mass spectrometry, enhancing the capabilities of toxicological analyses (Kwon et al., 2021).
- Pharmacokinetic profiling: A study on the pharmacokinetics of Zolpidem and Zolpidem phenyl-4-carboxylic acid in oral fluid post administration provided crucial data for understanding drug behavior in therapeutic monitoring (Feng et al., 2019).
- Forensic case study: An examination of a fatal zolpidem poisoning case highlighted the postmortem distribution and redistribution of Zolpidem and its predominant metabolite, Zolpidem phenyl-4-carboxylic acid, in body fluids and tissues, offering insights for forensic pathology (Hasegawa et al., 2018).
法律信息
Ambien is a registered trademark of Sanofi S.A.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Stilnox is a registered trademark of Sanofi S.A.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
监管及禁止进口产品
John H Lewis et al.
Journal of analytical toxicology, 31(4), 195-199 (2007-06-09)
Zolpidem is a non-benzodiazepine hypnotic that has been implicated in both drug-facilitated sexual assault and drink spiking. Detection of the drug in urine is extremely difficult because of its extensive metabolism. A method is presented for the detection and quantitation
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