推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
C[NH+]1CCN(CC1)C(=O)OC2N(C(=O)c3nccnc23)c4ccc(Cl)cn4
InChI
1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/p+1
InChI key
GBBSUAFBMRNDJC-UHFFFAOYSA-O
一般描述
经过认证的溶液标准，适用于临床毒理学、法医分析、药学研究或尿液药物测试的LC/MS或GC/MS应用中。 佐匹克隆是一种非苯二氮卓类催眠药，商品名为Imovane®和ZImovane®，处方用于治疗失眠。
应用
- 佐匹克隆溶液的药理学研究应用：用于开发和验证用于检测生物样品中Z类药物（z-drug）的分析方法，改进法医毒理学和临床诊断（Chauhan et al., 2024）。
- 作为生物化学领域GABA受体调节剂的佐匹克隆：考察了其在毒品辅助性犯罪中的作用，特别是通过假定性现场测试（ presumptive spot test）进行鉴定，这对法医分析至关重要Chauhan and Sharma, 2023).
- 用于睡眠障碍实验研究的佐匹克隆溶液：分析了其对死者血液高脂血症的影响，为法医学和医学研究做出贡献（Elenstål et al., 2023）。
- 佐匹克隆液体制剂在实验室条件下的稳定性：研究对失眠治疗中的长期用药进行了考察，提供了有关临床安全性和有效性的基本数据（Zee et al., 2023）。
- 佐匹克隆体外受体结合测定方法：佐匹克隆被用于评估佐匹克隆杂质的毒性，该研究为更安全药品的开发提供支持（Yin et al., 2023）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Imovane is a registered trademark of Sanofi-Aventis
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
监管及禁止进口产品
Coma after single dose of zopiclone.
Annelie K Hintzen et al.
The American journal on addictions, 21(3), 291-291 (2012-04-13)
Judith Peacey et al.
The Journal of nervous and mental disease, 200(1), 83-87 (2012-01-03)
Adult patients (N = 100) being treated for acute psychiatric illness were interviewed about their sleep problems and attitudes toward available treatments. Most (74%) were using at least one prescribed psychotropic drug with hypnotic or sedative effects. Participants prescribed three
[Determination of zopiclone in serum by gas chromatographic method].
Zi-ru Cheng et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 30(4), 314-315 (2012-07-19)
Julia Boyle et al.
Journal of clinical psychopharmacology, 32(5), 704-709 (2012-08-29)
Next-day residual effects of single evening doses of 3 mg of eszopiclone, 7.5 mg of zopiclone, and placebo were assessed in a randomized, double-blind, placebo-controlled, 3-way crossover study that used a mild sleep restriction protocol (sleep duration, 7 hours). During
To breathe, perchance not to wake?
David M Rapoport
Journal of applied physiology (Bethesda, Md. : 1985), 112(2), 247-248 (2011-10-29)
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