推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
2-8°C
SMILES字符串
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
InChI key
BHUYWUDMVCLHND-UHFFFAOYSA-N
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一般描述
α-羟基三唑仑是苯二氮卓类药物三唑仑（一种用于治疗严重失眠的药物）的主要尿液和血液代谢产物。该认证溶液标准品适用于临床毒理学、法医学分析、尿液药物检测或药物研究的 LC/MS 或 GC/MS 应用。
应用
- 苯二氮卓类药物的药代动力学分析：α-羟基三唑仑溶液可用于以LS/MS法进行生物体液中苯二氮唑类药物及其代谢物的定量测定，该研究获得了准确的药代学特征，这对临床和法医分析至关重要（Zheng et al., 2018）。
- 受体结合研究：高纯度α-羟基三唑仑可用于受体结合研究，这种应用使研究人员能够从分子水平上阐明苯二氮卓类类似物的相互作用机制，从而加深我们对其药理作用的理解（Minegishi et al., 2021）。
- 分析方法的开发: α-羟基三唑仑溶液是一种关键分析标准品，可用于开发稳健分析方法进行各种基质中苯二氮卓类药物的检测和测定，有助于毒理学和药理学研究的进展（Lahr et al., 2020）。
- 法医和临床毒理学：在法医学中，α-羟基三唑仑溶液有助于我们快速测定尿液样本中的苯二氮卓类及其代谢物，这对准确解释毒理学数据至关重要（Jeong et al., 2015）。
- 生化领域科学研究：α-羟基三唑仑研究化合物对于我们研究三唑仑和相关苯二氮卓类药物的代谢途径和降解特征至关重要，为生物化学家进行药物代谢和药代动力学研究提供了支持 (Jin et al., 2011）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
监管及禁止进口产品
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
Fumio Moriya et al.
Legal medicine (Tokyo, Japan), 5 Suppl 1, S91-S95 (2003-08-26)
A 57-year-old man was found dead lying down in a bamboo thicket. Moderate to severe petechiae were present on his conjunctivae, buccal mucosa, and laryngeal mucosa at autopsy. Cardiac chambers contained a normal volume of fluid blood. Moderate atherosclerosis and
O Dehlin et al.
European journal of clinical pharmacology, 25(1), 91-94 (1983-01-01)
Serum triazolam levels were determined in eight geriatric patients (average age 80 years) on Days 1 and 7 of administration of triazolam 0.25 mg once daily, 1 h after a standard breakfast. Triazolam was rapidly absorbed reaching average peak concentrations
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