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Merck
CN
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文件

安全信息

T-058

Supelco

Tapentadol hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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别名:
Tapentadol hydrochloride solution
经验公式（希尔记法）:
C14H23NO · HCl
CAS号:
175591-09-0
分子量:
257.80
EC 号:
200-659-6
MDL编号:
MFCD00944992
UNSPSC代码:
41116107
PubChem化学物质编号:
329826275
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1.0 mg/mL in methanol (as free base)

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

格式

single component solution

储存温度

−20°C

SMILES字符串

Cl.CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1

InChI

1S/C14H23NO.ClH/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12;/h6-9,11,14,16H,5,10H2,1-4H3;1H/t11-,14+;/m0./s1

InChI key

ZELFLGGRLLOERW-YECZQDJWSA-N

基因信息

human ... OPRM1(4988) , SLC6A2(6530)

相关类别

一般描述

Tapentadol represents the first new drug of the centrally-acting analgesic class approved in the US in more than 25 years. This Snap-N-Spike® Reference Solution is suitable for many LC/MS or GC/MS applications, including forensic analysis, pharmaceutical analysis, pain prescription monitoring, and urine drug testing.

应用

  • Extended-Release Formulation for Chronic Pain: Extended-release formulations of Tapentadol hydrochloride are developed to provide sustained pain relief for chronic conditions. This formulation reduces the frequency of dosing and enhances patient compliance, offering consistent pain management (Faria et al., 2017).
  • Pharmaceutical Quality Control and Research: High-purity Tapentadol hydrochloride solutions are essential in pharmaceutical research and quality control. These solutions are used for the calibration of analytical instruments and ensuring the consistency and safety of pharmaceutical products (Fejos et al., 2014).
  • Transdermal Delivery Systems: Innovative research has developed PEGylated ultra-deformable transferosomes for the transdermal delivery of Tapentadol, improving its bioavailability and analgesic activity. This method offers a non-invasive alternative for pain management (Deng et al., 2022).
  • Innovative Pain Management Solutions: Research on new delivery methods, such as intranasal administration using chitosan nanoparticles, aims to enhance the therapeutic potential and patient compliance of Tapentadol hydrochloride solution for pain management (Javia & Thakkar, 2017).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

相关产品

产品编号
说明
价格

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

监管及禁止进口产品

分析证书(COA)

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实验方案

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 After Solid Phase Extraction (SPE) Using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

使用UHPLC/MS（TOF）检测不同酶水解条件处理的尿液中药物和代谢物

为了使用β-葡糖醛酸酶优化水解，必须对每种待分析的葡糖苷酸代谢物进行某些因素的评估，例如孵育时间、温度、水解pH、酶源和酶浓度。

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

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