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安全信息

T-049

Supelco

他克莫司 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C44H69NO12
CAS号:
104987-11-3
分子量:
804.02
MDL编号:
MFCD00869853
UNSPSC代码:
41116107
PubChem化学物质编号:
329826607
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in acetonitrile

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

−70°C

SMILES字符串

CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC

InChI

1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChI key

QJJXYPPXXYFBGM-LFZNUXCKSA-N

基因信息

human ... FKBP1A(2280)

相关类别

一般描述

他克莫司，也称或藤霉素，是一种免疫抑制药物，用于预防器官移植排斥反应。该经认证的加标溶液®适合用作制备他克莫司检测方法（LC-MS/MS）的校准品和对照品的起始物料。他克莫司以商品名Progaf、Advagraf®和Protopic®出售。

法律信息

Advagraf is a registered trademark of Astellas Pharma Inc.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Protopic is a registered trademark of Astellas Pharma Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

35.6 °F - closed cup

闪点(°C)

2 °C - closed cup

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Markus Riegersperger et al.
Transplantation, 95(11), 1338-1345 (2013-04-19)
Endothelial progenitor cell (EPC) counts are proposed surrogate markers for vascular function and cardiovascular risk. The effect of tacrolimus (TAC) on EPC is unknown. In this randomized controlled trial, we assigned 148 stable long-term kidney transplant recipients (KTR) to maintaining
Darla R Lower et al.
American journal of clinical pathology, 139(6), 788-792 (2013-05-22)
FK506 (tacrolimus), a macrolide immunosuppressant, is widely used in pediatric transplant patients, but a relatively narrow therapeutic window in children vs adults requires close and accurate monitoring of whole blood FK506 levels. High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS/MS)-based assays have
Kensuke Kosugi et al.
Cranio : the journal of craniomandibular practice, 31(2), 140-150 (2013-06-26)
The authors performed a longitudinal study of the microstructural changes occurring in the mandibular condyle during osteoporosis using the findings obtained from micro-CT. The subjects used in this study were eight Sprague-Dawley rats. Among them, five were administered the immunosuppressant
[Successful effect of tacrolimus in a 5-year-old boy presenting with repeated episodes of non-herpetic acute limbic encephalitis].
K Kishi et al.
No to hattatsu = Brain and development, 45(2), 152-154 (2013-05-09)
A Osama Gaber et al.
Transplantation, 96(2), 191-197 (2013-05-30)
LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Prograf)
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