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Merck
CN

S-025

Supelco

大麻素JWH-018标准液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式(希尔记法):
C24H23NO
分子量:
341.45
EC 号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

浓度

100 μg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology
forensics and toxicology

格式

single component solution

储存温度

−20°C

InChI

1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3

InChI key

JDNLPKCAXICMBW-UHFFFAOYSA-N

一般描述

JWH-018是在几种版本的草药混合物“香料”中发现的合成大麻素。这种香料大麻素的非法使用集中在其精神活性作用上,该作用模仿了大麻中Δ9-THC的作用。尽管JWH-018比类似量的大麻有效得多,但对于通过典型的Δ9-THC检测方法进行检测也提出了重大挑战。
2009年7月,美国禁毒署(DEA)将JWH-018列入其关注的药物和化学物质清单。除了据报道在俄亥俄州和佛罗里达州缉获香料外,一些州还通过了立法行动,限制了JWH-018的销售或拥有,包括阿拉巴马州,阿肯色州,乔治亚州,堪萨斯州,肯塔基州,北达科他州和田纳西州。

应用


  • Investigating Synthetic Cannabinoids in Leukemia: A study exploring the effects of synthetic cannabinoids like JWH-018 on leukemia and leukemic stem cells offers insights into potential therapeutic applications. This research highlights the value of JWH-018 as a tool for understanding cancer pathogenesis and developing new treatments, reinforcing its significance in biomedical research (Salcin et al., 2024).

    • Yeast Biosensor for Cannabinoid Detection: Research on a GPCR-based yeast biosensor for point-of-use cannabinoid determination, including synthetic cannabinoids such as JWH-018, showcases innovative biotechnological applications. This study demonstrates the biosensor′s utility in biomedical and environmental monitoring, potentially influencing drug safety and public health strategies (Miettinen et al., 2022).

    • Molecular Signaling of Synthetic Cannabinoids: A comparative study on the molecular signaling of synthetic cannabinoids, including JWH-018, provides critical data on their effects on CB1 and CB2 receptors. This research is pivotal for pharmacological studies aiming to understand the complex interactions of these compounds at the molecular level, thereby aiding in the development of targeted therapies for various conditions (Andersen et al., 2021).

    • Enhancing Drug Analysis Sensitivity: A study aimed at enhancing the nonfouling properties and sensitivity of Surface-Enhanced Raman Scattering (SERS) substrates for potent drug analysis, including JWH-018, highlights its application in forensic science. This research contributes to more accurate and rapid detection methods, essential for effective law enforcement and therapeutic monitoring (Masterson et al., 2021).




法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

监管及禁止进口产品

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商品

This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

Chromatograms

application for HPLCapplication for HPLCapplication for HPLC

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