推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
−20°C
SMILES字符串
Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI
1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI key
SCUMDQFFZZGUQY-UHFFFAOYSA-N
一般描述
利他林酸®是哌甲酯的主要血液代谢产物，哌甲酯是一种精神兴奋药，商品名为 Concerta ®和 Ritalin®。该认证的 Snap-N-Spike ®溶液适用于尿液药物检测、临床毒理学和法医学分析的 LC/MS 或 GC/MS 应用。哌甲酯用于治疗注意力缺陷多动障碍 (ADHD)、心动过速和嗜睡症。
应用
- 非人灵长类动物的遗传毒性研究：利他林酸盐酸盐（ritalinic acid hydrochloride）是派醋甲酯的主要代谢产物，在遗传毒理学研究中用于评估潜在的遗传毒性作用，有助于评估神经药理学治疗的安全性 （Morris et al., 2009）。
- 药代动力学和致突变性研究：利他林酸盐酸盐可用于剂量范围和致突变性研究。它有助于研究哌醋甲酯的药代动力学和毒理学影响，为其在治疗应用中的安全性和有效性提供重要见解（Manjanatha et al., 2008）。
- 生物等效性和食物效应研究：在临床药理学中，利他林酸盐酸盐有助于进行右哌醋甲酯的生物等效性研究，考察了食物对药物吸收和代谢的影响，这对于药物给药方案的优化至关重要（Teo et al., 2004）。
- 儿童药物治疗：采用利他林酸盐酸盐进行的研究探讨了哌醋甲酯在进食或不进食情况下的给药效果，强调了其对药物及其酸性代谢物血浆浓度的影响，为儿科剂量指南提供了信息（Chan et al., 1983）。
- 多动症治疗研究：利他林酸盐酸盐为多动症儿童的药代动力学研究提供支持，有助于了解哌醋甲酯在体内的行为，从而改进治疗策略（Hungund et al., 1979）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Marion Letzel et al.
Chemosphere, 81(11), 1416-1422 (2010-10-12)
To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface water and bank filtrate
A Solans et al.
Journal of chromatography. B, Biomedical applications, 658(2), 380-384 (1994-08-19)
Two analytical methods for the simultaneous detection in urine of methylphenidate and its main metabolite, ritalinic acid, are described. Both procedures are based on solid-phase extraction of urine samples on Bond Elut Certify columns, and capillary gas chromatographic-mass spectrometric detection
J S Markowitz et al.
Journal of clinical psychopharmacology, 19(4), 362-366 (1999-08-10)
Methylphenidate is the most commonly prescribed psychostimulant in clinical use today. Known methylphenidate metabolites include ritalinic acid, corresponding lactams, and p-hydroxymethylphenidate. Recent in vitro work using rat liver preparations has indicated that the methylphenidate ethyl ester, ethylphenidate, is formed upon
Martin Josefsson et al.
Journal of pharmaceutical and biomedical analysis, 55(5), 1050-1059 (2011-04-19)
A validated, accurate and sensitive LC-MS/MS method for determination of racemic methylphenidate and its metabolite ritalinic acid has been developed. The analytes were quantified by tandem mass spectrometry operating in positive electrospray ionization mode with multiple reaction monitoring. Blood, plasma
Nicolas Barbarin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 783(1), 73-83 (2002-11-27)
This work presents a high-throughput selected reaction monitoring (SRM) LC-MS method for the determination of methylphenidate (MPH), a central nervous stimulant, and its de-esterified metabolite, ritalinic acid (RA) in rat plasma samples. A separation of these two compounds was achieved
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