等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
drug control
Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
格式
single component solution
储存温度
2-8°C
InChI
1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
InChI key
JTJMJGYZQZDUJJ-UHFFFAOYSA-N
一般描述
苯环利啶，通常称为PCP，是一种具有致幻作用和神经毒性作用的娱乐性药物。 PCP具有“天使尘埃”或“wet”之类的街道名称，呈粉末或液体形式。非法形式的药物通常喷雾至多叶材料（例如大麻）上，然后进行抽吸。此认证溶液标准品可作为校准物和对照品中的起始材料，通过LC/MS或GC/MS，用于从法医分析和临床毒理学到尿液药物测试方面的各种应用中。
苯环利啶，通常称为PCP，是一种具有致幻作用和神经毒性作用的娱乐性药物。PCP具有“天使尘埃”或“wet”之类的街道名称，呈粉末或液体形式。非法形式的药物通常喷雾至多叶材料（例如大麻）上，然后进行抽吸。此认证溶液标准品可作为校准物和对照品中的起始材料，通过LC/MS或GC/MS，用于从法医分析和临床毒理学到尿液药物测试方面的各种应用中。
应用
- A Collaborative Platform for Novel Compound Identification - Characterization of Designer Phencyclidines (PCPs) POXP, PTHP, and P2AP: This research highlights a collaborative platform for the identification and characterization of novel designer PCPs, emphasizing their potential as analytical standards and sigma receptor agonists. The study provides valuable insights for scientists involved in receptor binding studies and the development of dissociative anesthetics for research (Sisco, Urbas, 2023).
- Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction: Investigating the long-term effects of NMDAR hypofunction in mice, this study uses PCP to elucidate mechanisms of schizophrenia, showcasing its application as a NMDA receptor antagonist in neuropharmacological studies. The findings are crucial for advancing knowledge on neurotransmitter research and mental health disorders (Ponserre et al., 2024).
- 3-Methoxy-Phencyclidine Induced Psychotic Disorder: A Literature Review and an (18)F-FDG PET/CT Case Report: This review and case report discuss the psychiatric implications of 3-Methoxy-Phencyclidine, a derivative of PCP, providing insights into its effects on human cognition and behavior. Such studies are essential for developing high-purity PCP liquids for sigma receptor assays and understanding its role as a non-competitive NMDA antagonist (Pepe et al., 2024).
- Trips Through the Skin: Reviewing Cutaneous Drug Reactions to Psychedelics and Hallucinogens: This review explores the dermatological reactions associated with psychedelic drugs, including PCP. It underscores the importance of understanding the biochemical pathways affected by PCP, reinforcing its utility as a research chemical in pharmaceutical applications (Rahman et al., 2024).
- Novel α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator LT-102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia: This research explores the potential therapeutic uses of AMPAR potentiators, highlighting PCP′s role in enhancing understanding of glutamatergic dysfunction in schizophrenia. It showcases PCP′s utility in developing treatments that modulate neurotransmitter systems, valuable for neuropharmacology research (Qi et al., 2024).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
监管及禁止进口产品
Ross Zimnisky et al.
Psychopharmacology, 226(1), 91-100 (2012-10-20)
A major challenge in the pharmacological treatment of psychotic disorders is the effective management of the associated cognitive dysfunctions. Novel concepts emphasize a potential benefit of partial agonists acting upon dopamine D(2)-like receptors in ameliorating these cognitive deficits, and pre-clinical
Daniel C Javitt et al.
Schizophrenia bulletin, 38(5), 958-966 (2012-09-19)
Over the last 20 years, glutamatergic models of schizophrenia have become increasingly accepted as etiopathological models of schizophrenia, based on the observation that phencyclidine (PCP) induces a schizophrenia-like psychosis by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. This article reviews
Ramin Hajikhani et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 21(3), 307-312 (2012-12-12)
The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test. Phencyclidine and its derivatives (M, F, L, B, S
Jens Köhler et al.
Journal of medicinal chemistry, 55(20), 8953-8957 (2012-09-28)
We synthesized and investigated the NMDA and σ₁ receptor affinity of enantiomerically pure 2-(2-phenyl-1,3-dioxan-4-yl)ethanamines 17-26. The primary amines (R,R)-18-20 with an axially oriented phenyl moiety in position 2 interacted with high enantioselectivity (eudismic ratios 70-130) and high affinity (K(i)((R,R)-19) =
Masakuni Horiguchi et al.
Behavioural brain research, 238, 36-43 (2012-09-29)
Development of dopamine (DA) D(1) receptor agonists is a priority to improve cognitive impairment in schizophrenia (CIS). This study examined the dose-response relationship of the selective D(1) agonist, SKF38393 (0.5-40 mg/kg), to reverse the deficit in novel object recognition (NOR)
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