推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24
InChI
1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
InChI key
KVWDHTXUZHCGIO-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)
一般描述
用于 LC/MS 或 GC/MS 应用（包括临床毒理学分析或治疗药物监测）的分析引用标准品。奥氮平商品名称再普乐 ®，是一种非典型抗精神病药物，用于治疗精神分裂症和双相情感障碍。
应用
- 奥氮平对双相情感障碍患者的代谢影响：一项随机对照试验的网络元分析（network meta-analysis）评估了抗精神病药物和情绪稳定剂（包括奥氮平）对双相情感障碍患者的代谢影响，该研究提供了有关其药效学特性和治疗优化的见解（Kong et al., 2024）。
- 精神分裂症研究中的机器学习：研究人员使用机器学习来预测精神分裂症谱系障碍患者的暴力行为，通过系统性综述来评估奥氮平的有效性。这项研究强调了抗精神病药物治疗分析在改善患者特异性治疗策略方面的相关性（Delvecchio et al., 2024）。
- 溶解性和生物利用度的提高：研究的重点是对聚合物基质的评估，该聚合物基质可以将奥氮平等水溶性较差的药物负载到介孔二氧化硅中。本研究促进了更有效、生物可利用更高的奥氮平口服液制剂的开发（Barmpalexis et al., 2024）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Zyprexa is a registered trademark of Eli Lilly and Co.
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
危险化学品
Joseph P McEvoy et al.
The Journal of clinical psychiatry, 74(2), 170-179 (2013-03-12)
To examine the effectiveness of switching patients to lurasidone using 3 different dosing strategies. Adults with DSM-IV-defined schizophrenia or schizoaffective disorder in a nonacute phase of illness were randomized to 1 of 3 lurasidone dosing regimens for the initial 2
Mao M Söderberg et al.
Pharmacogenetics and genomics, 23(5), 279-285 (2013-03-16)
Metabolism of the atypical antipsychotic olanzapine (OLA) is partially catalyzed by cytochrome P450 (CYP) 1A2, a target of aryl hydrocarbon receptor (AHR)-mediated induction. We investigated the influence of four cis-acting polymorphisms (rs2470893C>T and rs2472297C>T between CYP1A1 and CYP1A2 loci, and
Jean A Milstein et al.
PloS one, 8(2), e57308-e57308 (2013-02-26)
Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug treatment. Most antipsychotic drugs are potent antagonists or partial agonists of
Heating under high-frequency inductive conditions: application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa).
Jan Hartwig et al.
Angewandte Chemie (International ed. in English), 52(37), 9813-9817 (2013-07-31)
A B Petersen et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 39-43 (2013-12-10)
In 2012, Danish psychiatrist raised concerns regarding the use of high-dose olanzapine in the treatment of patients. The present study was part of an audit carried out by the Mental Health Services of the Capitol Region of Denmark regarding this
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