等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChI key
SHAYBENGXDALFF-UHFFFAOYSA-N
基因信息
human ... SLC6A2(6530) , SLC6A4(6532)
一般描述
去甲替林是第二代三环类抗抑郁药（TCA），商品名为Sensoval、Aventyl和Pamelor，用于治疗重度抑郁症。®®去甲替林也是TCA阿米替林的活性代谢物。该认证Snap-N-Spike®溶液适合通临床毒理学、法医分析、尿液药物测试或药物监测中的LC/MS或GC/MS应用。
应用
- Neuropharmacological research: A study explored the effectiveness of antidepressants in combination with psychotherapy, including nortriptyline hydrochloride. This research emphasizes its role in treating mental health disorders, showcasing the compound′s importance in neuropharmacological research and its potential for further exploration in neurotransmitter studies (Alemi et al., 2024).
- Peripheral neuropathy treatment: Nortriptyline hydrochloride was evaluated for its efficacy in managing diabetic peripheral neuropathy, highlighting its therapeutic benefits beyond traditional antidepressant applications. This study underlines its utility in biochemical assays aimed at understanding its mechanism of action on neurophysiological pathways (Bragg et al., 2024).
法律信息
Aventyl is a registered trademark of Eli Lilly and Co.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Pamelor is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
危险化学品
Escitalopram versus nortriptyline: how to let the clinical GENDEP data tell us what they contained.
P Bech et al.
Acta psychiatrica Scandinavica, 127(4), 328-329 (2013-03-14)
Robert A Power et al.
Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)
Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a
Chiara Vladiskovic et al.
Journal of pharmaceutical sciences, 101(12), 4481-4489 (2012-09-19)
Nortriptyline hydrochloride, a tricyclic antidepressant, appears in two different polymorphic forms, only one of which (hereafter, form β) has been previously characterized by single-crystal analysis. Form β is monoclinic, P2(1)/c, with a = 5.070(2), b = 34.088(5), c = 9.976(1)
Karim Malki et al.
Pharmacogenetics and genomics, 22(11), 765-776 (2012-10-03)
Monoaminergic imbalances play a role in the pathogenesis of depression and most common antidepressant drugs act on monoamine neurotransmitters. However, the lag time between restoring neurochemical balance and symptom improvement suggests that the response to drugs involves complex biological events
Abbul Bashar Khan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 119-124 (2012-07-04)
To know the interaction of amphiphilic drugs nortriptyline hydrochloride (NOT) and promazine hydrochloride (PMZ) with serum albumins (i.e., human serum albumin (HSA) and bovine serum albumin (BSA)), techniques of UV-visible, fluorescence, and circular dichroism (CD) spectroscopies are used. The binding
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