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Merck
CN

N-906

Supelco

硝西泮标准液 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式(希尔记法):
C15H11N3O3
CAS号:
分子量:
281.27
EC 号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

浓度

1.0 mg/mL in acetonitrile

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1

InChI

1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)

InChI key

KJONHKAYOJNZEC-UHFFFAOYSA-N

一般描述

一种适合在LC/MS或GC/MS检测方法中用作氯硝西泮校准物和对照品起始材料的认证溶液标准品。氯硝西泮是一种用于治疗严重失眠的苯二氮卓类药物。该药物是以商品名Mogadon,、Nitrados和Somnite进行销售的。

应用

  • 镇静药药理学研究中的硝西泮研究用溶液:硝西泮是一种苯二氮卓类药物,广泛应用于药理学研究,重点是其镇静作用。研究探讨了它对中枢神经系统的影响及其对睡眠障碍和焦虑的潜在治疗应用(Bhoir et al., 1999)。
  • 硝西泮的神经科学研究应用:该溶液对神经科学研究非常重要,对于那些考察苯二氮卓类药物对GABA能系统调节作用的研究来说更是如此。研究人员利用硝西泮来阐明苯二氮卓类药物影响神经递质释放和神经元兴奋性的机制(Honeychurch et al., 2006)。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

FlameExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

35.6 °F - closed cup

闪点(°C)

2 °C - closed cup

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mihalj Posa et al.
Colloids and surfaces. B, Biointerfaces, 74(1), 84-90 (2009-07-28)
Critical micellear concentrations (CMC) were determined for two novel promoters of membrane permeability-7-monoketocholic acid (7-MKC) and 12-monoketocholic acid (12-MKC), using two non-invasive ((1)H NMR relaxation experiment and conductometry) and two invasive (spectral shift and partition coefficient of the probe molecule)
Mihalj Poša et al.
Colloids and surfaces. B, Biointerfaces, 86(2), 285-291 (2011-05-07)
The formation of mixed micelles built of 7,12-dioxolithocholic and the following hydrophobic bile acids was examined by conductometric method: cholic (C), deoxycholic (D), chenodeoxycholic (CD), 12-oxolithocholic (12-oxoL), 7-oxolithocholic (7-oxoL), ursodeoxycholic (UD) and hiodeoxycholic (HD). Interaction parameter (β) in the studied
Masatomo Suetsugi et al.
Progress in neuro-psychopharmacology & biological psychiatry, 31(4), 839-847 (2007-03-03)
The first-night effect is a well-known phenomenon that is considered to result from a subject's lack of adaptation to the unfamiliar environment of a sleep laboratory and to the technical equipment used for polysomnography. The effect has been explored as
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Pongsakdi Visudhiphan
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 90(10), 2244-2244 (2007-11-29)
János Gidai et al.
Pharmacoepidemiology and drug safety, 19(2), 175-182 (2009-12-10)
To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self-poisoning pregnant women model. Comparative analysis of exposed children and their unexposed sibs born

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