推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
(Snap-N-Spike®)
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v))
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
ClC1=CC2=C(N=C(N)C[N+]([O-])=C2C3=CC=CC=C3)C=C1
InChI
1S/C15H12ClN3O/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19(20)9-14(17)18-13/h1-8H,9H2,(H2,17,18)
InChI key
LNLMGKOHYYEWMY-UHFFFAOYSA-N
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一般描述
Norchlordiazepoxide is a major urinary metabolite of the benzodiazepine chlordiazepoxide, indicated for short term treatment of severe anxiety and for the management of acute alcohol withdrawal syndrome. The metabolite, also known as N-desmethylchlordiazepoxide, is pharmacologically active. This Certified Spiking Solution® is suitable for GC/MS or LC/MS methods in chlordiazepoxide testing for forensic analysis, urine drug testing, or clinical toxicology.
应用
- Immunoassay detection of benzodiazepines: A study assessed the efficacy of immunoassays in detecting benzodiazepines and their metabolites in blood, including Norchlordiazepoxide. This research is vital for clinical toxicology and forensic applications, providing essential insights into drug monitoring and abuse detection (Huang & Moody, 1995).
- High-performance liquid chromatographic method: A method for determining clonazepam and other benzodiazepines in serum was developed, applicable to Norchlordiazepoxide. This technique underscores the compound′s clinical relevance and enhances pharmacokinetic and therapeutic drug monitoring (Haver et al., 1986).
- Photolytic derivatization for LCEC: Research highlighted the use of photolytic derivatization to improve the determinations of pharmaceuticals, including benzodiazepines like Norchlordiazepoxide, in biological fluids. This study contributes to the advancements in analytical chemistry, improving the accuracy of drug level assessments (Selavka et al., 1985).
- Postmortem stability of benzodiazepines: An investigation into the postmortem stability of benzodiazepines in blood and tissues provided critical data for forensic sciences, particularly regarding the stability of compounds like Norchlordiazepoxide after death, aiding in legal and medical examinations (Levine et al., 1983).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2.0 °C - closed cup
法规信息
监管及禁止进口产品
Hyun-Sun Jeon et al.
Dental materials journal, 36(4), 476-481 (2017-04-20)
The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated
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