N-079
(R,S)-Norcotinine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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关于此项目
经验公式（希尔记法）:
C9H10N2O
化学文摘社编号:
分子量:
162.19
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
InChI
1S/C9H10N2O/c12-9-4-3-8(11-9)7-2-1-5-10-6-7/h1-2,5-6,8H,3-4H2,(H,11,12)
SMILES string
O=C1NC(C2=CN=CC=C2)CC1
InChI key
FXFANIORDKRCCA-UHFFFAOYSA-N
grade
certified reference material
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
format
single component solution
storage temp.
−20°C
Quality Level
General description
Norcotinine, or desmethylcotinine, is a urinary metabolite of nornicotine and cotinine found in smokers and users of other nicotine products including chewing tobacco and snuff. This Certified Spiking Solution® is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
49.5 °F
flash_point_c
9.7 °C
法规信息
危险化学品
此项目有
Liza U Ljungberg et al.
Endothelium : journal of endothelial cell research, 15(5-6), 239-245 (2008-12-10)
Nicotine has been shown to induce endothelial dysfunction, which is an early marker of atherosclerosis. Nicotine undergoes extensive metabolism in the liver, forming a number of major and minor metabolites. There are very limited data on the effect of nicotine
Janne Hukkanen et al.
Clinical pharmacology and therapeutics, 80(5), 522-530 (2006-11-23)
Grapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit juice on the pharmacokinetics
N Eldirdiri et al.
European journal of drug metabolism and pharmacokinetics, 22(4), 385-390 (1998-03-26)
Since norcotinine and 4-(3-pyridyl)-4-oxobutyramide (POBAM) are probable metabolites of nicotine and cotinine, it was of interest to investigate the further in vitro metabolism of these compounds. We now report our preliminary findings using rat microsomal preparations (induced and/or non-induced with
Diaa M Shakleya et al.
Analytical and bioanalytical chemistry, 395(7), 2349-2357 (2009-10-20)
An analytical procedure was developed and validated for the simultaneous identification and quantification of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in 0.5 mL of human oral fluid collected with the Quantisal oral fluid collection device. Solid phase extraction and liquid chromatography-tandem
H Foth et al.
Toxicology and applied pharmacology, 105(3), 382-392 (1990-09-15)
Elimination parameters of [14C]nicotine in conscious rats receiving nicotine (0.3 mg/kg) either intravenously or orally were studied. The oral availability of unchanged nicotine, derived by comparison of the respective areas under the concentration vs time curves (AUC), was 89%, indicating
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