推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
−20°C
SMILES字符串
O=NN1CCCC1c2cccnc2
InChI
1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2
InChI key
XKABJYQDMJTNGQ-UHFFFAOYSA-N
一般描述
N′-亚硝基去甲烟碱，也称为NNN，是一种亚硝胺，是在包括鼻烟、香烟、咀嚼烟草和雪茄在内的多种烟草产品中发现的潜在致癌物。该经认证的加标溶液®适用于通过LC-MS/MS或GC/MS进行尼古丁检测或环境监测。
应用
- 用于定量测定咪多卡二丙酸盐的稳定性指示色谱法的验证；牛肉和牛奶样品中其残留物测定的应用。: 本研究开发并验证了使用硅胶60F₂₄TLC板定量测定牛肉和牛奶中定咪多卡二丙酸盐残留物的色谱方法，强调了该技术在复杂基质中的稳定性和可靠性（Sedik et al., 2020）。
- 在对氨基酚存在的情况下同时测定对乙酰氨基酚、 枸橼酸奥芬那君 和咖啡因的色谱方法的开发和验证；使用LC-MS/MS法定量测定对氨基酚的肾毒性杂质。: 本研究概述了硅胶60F-TLC板色谱法的开发和验证，该色谱法用于分析对乙酰氨基酚、枸橼酸奥芬那君和咖啡因及其肾毒性杂质，证明了该板在同时检测多种分析物的有效性（Boltia et al., 2020）。
- 通过RP-HPLC和TLC密度法同时定量测定防腐剂存在下的氯苯吡胺、苯肾上腺素、愈创甘油醚，并检测止咳糖浆中的相关物质愈创木酚。: 本研究开发了使用硅胶60F-TLC板的RP-HPLC和TLC密度测定法，用于定量测定咳嗽糖浆中的活性成分和防腐剂，展示了该板在药物质量控制中的实用性（Boltia et al., 2019）。
- 采用经过验证的色谱方法定量测定硝呋酰酚肼 胶囊中的合成遗传毒性杂质。: 这项工作验证了使用硅胶60F₂₄TLC板定量测定硝呋酰酚肼（nifuroxazide ）胶囊中具有遗传毒性杂质的色谱方法，强调了该板检测痕量污染物的精确度（Abdelwahab et al., 2018）。
- 高效薄层色谱法的开发、验证以及肾茶标准化提取物中四种化合物的同时定量测定。: 本研究提出了一种经过验证的硅胶60 F₂₄TLC板HPTLC方法，该方法可以同时定量测定草药提取物中的化合物，研究突出了色谱板在天然产物分析中的作用（Hashim et al., 2016）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
51.8 °F - closed cup
闪点(°C)
11.0 °C - closed cup
法规信息
危险化学品
N-Nitrosamines (15 listings): N-Nitrosonornicotine.
Report on carcinogens : carcinogen profiles, 12, 320-321 (2011-08-24)
Michael Urban et al.
Journal of analytical toxicology, 33(5), 260-265 (2009-08-13)
The tobacco-specific nitrosamine N'-nitrosonornicotine (NNN) is carcinogenic to humans (IARC Group 1). Assessing the tobacco smoke-related exposure to NNN by suitable biomarkers is of interest for risk evaluation. Recently, NNN and NNN-N-glucuronide have been quantified in urine of smokers. However
Jian-Min Yuan et al.
Carcinogenesis, 32(9), 1366-1371 (2011-07-08)
N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific nitrosamines. NNN and NNK can induce cancers of the esophagus and lung, respectively, in laboratory animals, but data on human esophageal cancer are lacking. The association between levels of NNN and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
Irina Stepanov et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(4), 945-948 (2008-04-10)
Specific biomarkers of tobacco carcinogen uptake are critical for investigations of the role of tobacco smoke exposure in human cancers. Two new biomarkers of human exposure to tobacco-specific carcinogens have been recently developed by our research group: urinary N'-nitrosonornicotine (NNN)
Panneerselvam Vijayaraj et al.
Antonie van Leeuwenhoek, 99(3), 567-577 (2010-11-04)
A tobacco-specific nitrosamine (TSNA), N-nitrosonornicotine (NNN), is a potent carcinogen present in cigarette smoke, and chronic exposure to it can lead to pulmonary cancer. NNN causes changes in phospholipid metabolism and the mechanism is yet to be elucidated. Exposure of
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