N-075
(±)-N′-亚硝基降烟碱 (NNN) 溶液
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
别名:
NNN, NNN 溶液
InChI
1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2
InChI key
XKABJYQDMJTNGQ-UHFFFAOYSA-N
SMILES string
O=NN1CCCC1c2cccnc2
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
Quality Level
General description
N′-亚硝基去甲烟碱，也称为NNN，是一种亚硝胺，是在包括鼻烟、香烟、咀嚼烟草和雪茄在内的多种烟草产品中发现的潜在致癌物。该认证加标溶液®适用于LC-MS/MS或GC/MS法尼古丁检测或环境监测。
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
51.8 °F - closed cup
flash_point_c
11.0 °C - closed cup
法规信息
危险化学品
此项目有
Hongwei Ou et al.
Se pu = Chinese journal of chromatography, 28(8), 754-758 (2011-01-26)
N-nitrosonornicotine (NNN), 4-( methylnitrosamino )-1-(3-pyridyl )-1-butanone (NNK), N-nitrosoanatabine (NAT) and N-nitrosoanabasine (NAB) are the most abundant carcinogens identified in tobacco and tobacco smoke. The accurate quantifications of NNN, NNK, NAT and NAB are necessary to evaluate its impact on the
Panneerselvam Vijayaraj et al.
Antonie van Leeuwenhoek, 99(3), 567-577 (2010-11-04)
A tobacco-specific nitrosamine (TSNA), N-nitrosonornicotine (NNN), is a potent carcinogen present in cigarette smoke, and chronic exposure to it can lead to pulmonary cancer. NNN causes changes in phospholipid metabolism and the mechanism is yet to be elucidated. Exposure of
Karen H Watanabe et al.
Regulatory toxicology and pharmacology : RTP, 55(2), 123-133 (2009-06-23)
The manner in which humans smoke cigarettes is an important determinant of smoking risks. Of the few investigators that have predicted cancer risks from smoking on a chemical-specific basis, most used mainstream cigarette smoke (MCS) carcinogen emissions obtained via machine
Jian-Min Yuan et al.
Carcinogenesis, 32(9), 1366-1371 (2011-07-08)
N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific nitrosamines. NNN and NNK can induce cancers of the esophagus and lung, respectively, in laboratory animals, but data on human esophageal cancer are lacking. The association between levels of NNN and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
Tobacco nitrosamine N-nitrosonornicotine as inhibitor of neuronal nicotinic acetylcholine receptors.
Ariane Nunes-Alves et al.
Journal of molecular neuroscience : MN, 49(1), 52-61 (2012-08-01)
Nitrosamines are well known for their carcinogenic potential. Recently, it was found that some of them may also interact with human nicotinic acetylcholine receptor (nAChR) subtypes. This work studied the effects of N-nitrosonornicotine (NNN) on recombinant rat α3β4 nAChR in
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