推荐产品
等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
格式
single component solution
储存温度
−20°C
SMILES字符串
Cl.COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c3ccccc3)N2
InChI
1S/C16H19NO4.ClH/c1-20-16(19)14-12-8-7-11(17-12)9-13(14)21-15(18)10-5-3-2-4-6-10;/h2-6,11-14,17H,7-9H2,1H3;1H/t11-,12+,13-,14+;/m0./s1
InChI key
RIPPXFWUYXTRNJ-BHARVXRSSA-N
一般描述
Norcocaine is a primary urinary metabolite of the popular recreation drug cocaine. Cocaine is a central nervous system stimulant with appetite suppressant and topical anesthetic properties. This certified solution standard is applicable for use in urine drug testing, clinical toxicology or forensic toxicology applications by GC/MS or LC/MS.
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
监管及禁止进口产品
Peter Kovacic
Medical hypotheses, 64(2), 350-356 (2004-12-21)
Cocaine is one of the principal drugs of abuse. Although impressive advances have been made, unanswered questions remain concerning mechanism of toxicity and addiction. Discussion of action mode usually centers on receptor binding and enzyme inhibition, with limited attention to
P Pellinen et al.
Archives of toxicology, 74(9), 511-520 (2000-12-29)
The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human
M G Ladona et al.
Life sciences, 68(4), 431-443 (2001-02-24)
Cocaine N-demethylation to norcocaine was studied in human liver microsomes of different ages. Norcocaine was formed at a considerable rate in fetal (45.4+/-18.2 nmol/mg x hour, n = 8) and adult specimens (82.0+/-46.6 nmol/mg x hour, n = 15), p
L Sun et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(9), 1183-1189 (2001-08-15)
To accurately assess the mechanism of involvement of the active metabolite norcocaine in the effects of oral cocaine, it is essential to determine the rate and extent of the formation of norcocaine. Although this study was designed specifically for this
Christine Moore et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859(2), 208-212 (2007-10-24)
A quantitative analytical procedure for the determination of cocaine, benzoylecgonine and cocaethylene and norcocaine in hair has been developed and validated. The hair samples were washed, incubated, and any drugs present were quantified using mixed mode solid-phase extraction and liquid
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