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等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−70°C
SMILES字符串
COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI
1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key
HPNSFSBZBAHARI-RUDMXATFSA-N
基因信息
human ... IMPDH1(3614) , IMPDH2(3615)
一般描述
在治疗药物监测中进行分析，以确保患者保持在药物治疗范围内，霉酚酸是一种免疫抑制药物，也是前药霉酚酸酯的活性代谢物。本分析标准适用于 LC-MS/MS 应用，包括治疗药物监测和其他临床或诊断应用。
应用
- 胃肠道毒性的靶向抑制：研究人员将霉酚酸用于肠道细菌中葡萄糖醛酸酶的靶向抑制研究，用于减轻麦考酚酸酯引起的胃肠道毒性。该应用对于我们改善免疫抑制治疗的病人恢复结果至关重要，体现了其在药物研究中的价值（Xia et al., 2024）。
- 协同免疫抑制疗法：该溶液可以与低剂量全身性免疫抑制治疗一起使用来维持血管化复合同种异体移植物（vascularized composite allograft ）的存活率，该应用突显了其在移植医学中的潜力。这项研究强调了霉酚酸在有效免疫抑制方案制定中的关键作用（Feturi et al., 2024).
- 遗传标记物的开发：研究人员将霉酚酸的生化特性用于开发解脂耶氏酵母的遗传标记物，研究证明了其在基因工程和生物技术发展中的重要性（Zhu et al., 2024）。
- 杀菌化合物的发现：该化合物可用于从芥子酸和霉酚酸中获取杀菌性酰肼先导化合物，研究阐明了其在农业生物化学和新型抗菌剂开发中的应用（Fang et al., 2023）。
制备说明
本品含有 1 mL 安瓿，浓度为 1.0 mg/mL 的乙腈溶液。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
危险化学品
E Kieslichova et al.
Transplantation proceedings, 45(2), 770-777 (2013-03-19)
The diagnosis of sepsis is difficult in immunocompromised patients owing to their modified response to infection. Our experiment in minipigs was designed to compare responses to sepsis between experimental groups of septic minipigs with and without immunosuppression. Minipigs with identical
L25. Medical treatment of subglottic stenosis in granulomatosis with polyangiitis (Wegener's).
Paul A Monach
Presse medicale (Paris, France : 1983), 42(4 Pt 2), 575-576 (2013-03-05)
Hui Chen et al.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 27(1), 35-38 (2013-07-17)
It is well known that cyclosporine A (CsA), a widely used immunosuppressant for clinical organ transplantation, has the ability to inhibit HCV replication. In this study, the effects of several other immunosuppressants, including mycophenolic acid (MPA), rapamycin and FK-506, on
David Wofsy et al.
Arthritis and rheumatism, 65(6), 1586-1591 (2013-03-27)
Clinical trials of therapies for lupus nephritis have used many different primary outcome measures, ranging from complete response to time to end-stage renal disease. The objective of this study was to compare several possible outcome measures, using data from a
CD25 blockade for refractory polymyositis.
Nicolò Pipitone et al.
Clinical and experimental rheumatology, 31(3), 474-474 (2013-03-08)
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