等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
pharmaceutical (small molecule)
格式
single component solution
储存温度
−20°C
SMILES字符串
[2H]C([2H])([2H])C(C(O)=O)C(O)=O
InChI
1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/i1D3
InChI key
ZIYVHBGGAOATLY-FIBGUPNXSA-N
一般描述
甲基丙二酸是一种丙二酸衍生物，是脂肪和蛋白质代谢中至关重要的中间体，在能量代谢中起关键作用。甲基丙二酸水平升高可由导致甲基丙二酸尿症的先天性代谢缺陷引起或表明早期维生素B<sub>12</sub>缺乏症。该内标物适用于在新生儿筛查和临床检测应用中通过LC/MS或GC/MS定量甲基丙二酸水平，以检测甲基丙二酸血症和诊断维生素B<sub>12</sub>缺乏症。
应用
- Assessment of Vitamin B-12 Status: Methyl-D3-malonic acid, as a deuterated derivative of malonic acid, was highlighted for its application in quantifying vitamin B-12 status using dried blood spots. This method provides a stable, precise measure and is useful in nutritional research and clinical diagnostics (Schroder et al., 2014).
- Improvement of Analytical Methods: Methyl-D3-malonic acid was used in a gas chromatography-mass spectrometry (GC-MS) technique to quantify methylmalonic acid in serum. This application underlines its role in improving diagnostic assays by offering enhanced precision and reliability in biochemical measurements (Straczek et al., 1993).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
美国出口管控1C298产品
危险化学品
Patrick J O'Hern et al.
eLife, 6 (2017-05-04)
Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss. Here, we report that reduced SMN function impacts the action of a pertinent microRNA
Laura Nadal et al.
Frontiers in aging neuroscience, 9, 24-24 (2017-02-24)
The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated
Alessandra Lo Cicero et al.
Scientific reports, 6, 34798-34798 (2016-10-16)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder that causes systemic accelerated aging in children. Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling opens up the possibility of access to
Laura Nadal et al.
Molecular brain, 9(1), 67-67 (2016-06-25)
The development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with different activities (the least active are punished)
Maria Bertuzzi et al.
Scientific reports, 8(1), 1988-1988 (2018-02-02)
While cholinergic neuromodulation is important for locomotor circuit operation, the specific neuronal mechanisms that acetylcholine employs to regulate and fine-tune the speed of locomotion are largely unknown. Here, we show that cholinergic interneurons are present in the zebrafish spinal cord
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