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Merck
CN

M-089

Supelco

(±)-美沙酮-D9标准液 CRM 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式(希尔记法):
C21D9H18NO
分子量:
318.50
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material

质量水平

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

格式

single component solution

储存温度

2-8°C

SMILES字符串

CC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])CC(C1=CC=CC=C1)(C(CC([2H])([2H])[2H])=O)C2=CC=CC=C2

InChI

1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/i1D3,3D3,4D3

InChI key

USSIQXCVUWKGNF-MXOMHCEVSA-N

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一般描述

A stable-labeled internal standard applicable for use in isotope dilution methods or quantitation of methadone levels by GC/MS or LC/MS in forensic analysis, urine drug testing, pain prescription monitoring or clinical toxicology applications. Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine®, Amidone, Methadose®, Physeptone, or Heptadon.

应用


  • Quantitative blood spot analysis: A sensitive LC-MS/MS assay was developed to quantify methaDoneand its metabolites in dried blood spots, demonstrating the application of Methadone-D₉ as an internal standard. This method offers a novel approach for monitoring methaDonelevels in patients, supporting drug metabolism and pharmacokinetic studies (Davari et al., 2020).

  • Molecular imprinting technique: A study employed molecularly imprinted polymer-sol-gel technology for micro-solid phase extraction of methadone, utilizing Methadone-D₉ for calibration in human plasma. This highlights its role in enhancing the accuracy of quantitative analyses in pharmaceutical research, particularly in the context of liquid chromatography-tandem mass spectrometry (El-Beqqali and Abdel-Rehim, 2016).

  • Forensic toxicology: A validated gas chromatography-mass spectrometry method was developed for simultaneous determination of methaDoneand its metabolites in umbilical cord plasma. Methadone-D₉ served as an internal standard, crucial for accurate measurement and forensic investigations (Nikolaou et al., 2008).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dolophine is a registered trademark of Roxane Laboratories, Inc.
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

相关产品

产品编号
说明
价格

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

危险化学品

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