推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
pharmaceutical (small molecule)
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CC(C(O)=O)C(O)=O
InChI
1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
InChI key
ZIYVHBGGAOATLY-UHFFFAOYSA-N
一般描述
甲基丙二酸是维生素B12 缺乏症和甲基丙二酸血症的指标。该经认证的加标溶液®适用于使用GC/MS或LC/MS制备临床和诊断测试中的校准品或质控品。
应用
- 用于代谢谱分析的有机酸分析：研究重点介绍了土壤微生物群和代谢组学的结合，将甲基丙二酸引入代谢分析，揭示了控释肥料如何影响甘蔗生长的见解，强调了化合物在农业生物技术中的作用 (Yuan et al., 2023）。
- 维生素B12缺乏症研究：在影响骨肉瘤中MAFB/NOTCH3轴的细胞机制研究中，甲基丙二酸是重要试剂，其水平可能反映与维生素B12缺乏相关的紊乱（perturbation），有助于我们更好地了解疾病进展Zhang et al., 2024).
- 质谱分析用甲基丙二酸标准品：在不同营养条件下对大豆根系的分析中，甲基丙二酸作为质谱标准品可以让我们更好地了解营养吸收机制，展示了其在植物生理学和生化研究中的实用性（Qin et al., 2023）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
危险化学品
Yu-peng Liu et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 50(6), 410-414 (2012-08-31)
Methylmalonic aciduria is the most common disorder of organic acidurias in the mainland of China. It is also the one of treatable metabolic disorders. The clinical spectrum of the patients varies from severe neonatal-onset forms with neonatal brain injury and
Acute renal failure potentiates methylmalonate-induced oxidative stress in brain and kidney of rats.
P F Schuck et al.
Free radical research, 47(3), 233-240 (2013-01-10)
Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. The disease is clinically characterized by progressive neurological deterioration and kidney failure, whose pathophysiology is still unclear. In the present work we investigated the effects of acute MMA
Takayuki Watanabe et al.
Journal of feline medicine and surgery, 14(12), 942-945 (2012-08-22)
A 10-year-old domestic shorthair cat showed anorexia, lethargy and ptyalism with hyperammonaemia. Portosystemic shunts were not identified by computed tomography angiography. Biopsy results revealed mild interstinal nephritis and no lesion in the liver. Analysis of urine revealed the presence of
Carla Dullemeijer et al.
The American journal of clinical nutrition, 97(2), 390-402 (2012-12-28)
Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. We
Setareh Shahab-Ferdows et al.
The Journal of nutrition, 142(10), 1881-1887 (2012-08-24)
A high prevalence of low serum vitamin B-12 concentrations has been reported in studies and surveys in Latin America including Mexico, but the functional consequences are unknown. This randomized controlled trial assessed the response to a high-dose vitamin B-12 supplementation
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