推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
drug control
Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
2-8°C
SMILES字符串
CC(CC1=CC=C(OCO2)C2=C1)NCC
InChI
1S/C12H17NO2/c1-3-13-9(2)6-10-4-5-11-12(7-10)15-8-14-11/h4-5,7,9,13H,3,6,8H2,1-2H3
InChI key
PVXVWWANJIWJOO-UHFFFAOYSA-N
一般描述
MDEA是苯丙胺和苯乙胺类的非法消遣性药物。该分析标准品适用于LC/MS或GC/MS应用，以进行临床毒理学研究、法医分析或尿液药物检测。MDEA是N-乙基苯丙胺的3，4-亚甲二氧基衍生物，因其迷幻作用而被滥用，类似于其结构类似物MDMA（摇头丸）。
应用
- 用于神经递质研究的（±）-MDEA溶液：在5-羟色胺释放机制的研究中（±）-MDEA-D3得到了广泛应用，它为考察神经递质动力学中涉及的生化途径提供了一种稳健的工具，这对神经药理学的进步至关重要（Wen et al., 2024）。
- 用于药理学研究的外消旋MDEA试剂：该溶液是新型精神活性物质合成和药理学评估的关键试剂，可以让研究人员阐明新型治疗剂的代谢和药效学特征（Boucenna et al., 2023）。
- 高纯度（±）-MDEA-D3标准物质：作为标准物质，这种高纯度物质是LC-MS/MS等分析仪器校准的必要试剂，可以确保定量药物分析和法医毒理学的准确性和可重复性（Ghorbani et al., 2020）。
- 用于LC-MS/MS的（±）-MDEA-D3 内标物：这种氘代MDEA可用作色谱分析的内标物，提高了复杂生物基质定量测定的精度（Tian et al., 2021）。
- 用于药物大麻素分析的（±）-MDEA-D3溶液：（±）-MDEA-D3可用于大麻素生物合成研究，有助于我们进行大麻素的分析和表征，为具有靶向治疗作用的大麻药物的开发提供支持 （Irani et al., 2018）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
监管及禁止进口产品
Emily Joy Jaehne et al.
Psychopharmacology, 201(2), 161-170 (2008-08-06)
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") disrupts thermoregulation in rats and can lead to life-threatening hyperthermia in humans. MDMA administration can also lead to long-term neurotoxicity in animals and possibly humans. The purpose of the current study was to extend previous results on
R W Romberg et al.
Journal of analytical toxicology, 35(1), 15-22 (2011-01-12)
This study evaluated the potential for partial separation of drugs from their deuterated internal standards using Cerex(®) Polycrom™ CLIN II solid-phase extraction (SPE) cartridges. After elution from the column and derivatization, gas chromatography-mass spectrometry results showed that the target compound
Jozef Hritz et al.
Journal of medicinal chemistry, 51(23), 7469-7477 (2008-11-13)
Cytochrome P450s (CYPs) exhibit a large plasticity and flexibility in the active site allowing for the binding of a large variety of substrates. The impact of plasticity and flexibility on ligand binding is investigated by docking 65 known CYP2D6 substrates
Tamer Awad et al.
Journal of chromatographic science, 48(9), 726-732 (2010-09-30)
Three regioisomeric 3,4-methylenedioxyphenethylamines having the same molecular weight and major mass spectral fragments of equal mass have been reported as drugs of abuse in forensic studies in recent years. These compounds are 3,4-methylenedioxy-N-ethylamphetamine (MDEA), 3,4-methylenedioxy-N,N-dimethylamphetamine (MDMMA), and N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB). A
Jin Young Kim et al.
Archives of pharmacal research, 31(12), 1644-1651 (2008-12-23)
A liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) method was developed and validated for the simultaneous detection and quantification of seven amphetamine derivatives (amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxy-N-amphetamine (MDA), 3,4-methylenedioxy-N-methamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), N,N-dimethylamphetamine (DMA), and N,N-dimethylamphetamine-N-oxide (DMANO)) in human urine.
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