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Merck
CN
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文件

安全信息

M-046

Supelco

吗啡-6- β-D-葡糖苷酸 溶液

1.0 mg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C23H27NO9
CAS号:
20290-10-2
分子量:
461.46
MDL编号:
MFCD00079434
UNSPSC代码:
41116107
PubChem化学物质编号:
329817792
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1.0 mg/mL in methanol: water (2:8)

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

格式

single component solution

储存温度

−20°C

SMILES字符串

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c35

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1

InChI key

GNJCUHZOSOYIEC-GAROZEBRSA-N

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相关类别

一般描述

经认证的浓度为1.0 mg/mL的吗啡-6-β-D-葡萄糖苷酸溶液标准品，用于大量样品检测。这种新的认证溶液标准适用于LCMS或GCMS应用，包括法医分析或尿液药物测试。

应用



  • High-efficacy opioid receptor agonist: Research identifies Morphine-6-β-ᴅ-glucuronide as having higher efficacy compared to morphine when acting as a mu-opioid receptor agonist in rat models, highlighting its potential for enhanced opioid research and applications in pain management (Osborne et al., 2000).


  • Application in clinical pharmacokinetics: A study developed and validated a liquid chromatography-mass spectrometry method for the simultaneous quantification of various analgesics and sedatives, including Morphine-6-β-ᴅ-glucuronide, aiding in clinical pharmacokinetic studies and potentially improving drug monitoring and safety in intensive care settings (Jutras et al., 2020).


法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

相关产品

产品编号
说明
价格

M-031

吗啡-3- β-D-葡糖醛酸 溶液, 1 mg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

M-003

吗啡-D3 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005

吗啡标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-006

吗啡-D3 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-017

Morphine-D3-3-β-D-glucuronide solution, 100 μg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

M-018

吗啡-3- β-D-葡糖醛酸 溶液, 100 μg/mL in methanol: water ( 50:50(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

M-030

吗啡标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-085

吗啡-D6标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

吗啡-D6标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-096

吗啡-6- β-D-葡糖苷酸 溶液, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 3 - STOT SE 1

靶器官

Eyes

WGK

WGK 2

闪点(°F)

109.4 °F

闪点(°C)

43 °C

法规信息

监管及禁止进口产品

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Claire Trécant et al.
European journal of medicinal chemistry, 46(9), 4035-4041 (2011-06-22)
Synthesis and biological evaluation of new derivatives of Morphine-6-Glucuronide (M6G) are described. M6G is an active metabolite of morphine which displays more analgesia than morphine with a superior side effect profile but with a less efficiently BBB penetration. These phenomena
Toyofumi Suzuki
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(10), 1445-1451 (2011-10-04)
Opioid analgesics exhibit cationic properties under physiological conditions, and the mechanism underlying permeation of the blood-brain barrier thus cannot be fully explained by simple diffusion alone. Various types of transporters that exhibit substrate specificity are localized on the blood-brain barrier
Senthilkumar Sadhasivam et al.
Journal of opioid management, 8(4), 217-226 (2012-09-04)
Interindividual variability in analgesic response and adverse effects of opioids because of narrow therapeutic indices are major clinical problems. Morphine is an opioid commonly used in children to manage perioperative pain. Al-though size and age often are considered primary covariates
Alexander T Nguyen et al.
European journal of pharmacology, 682(1-3), 86-91 (2012-03-01)
Previous studies have shown that morphine-6-glucuronide (M6G), a metabolite of morphine, induces reward and psychomotor stimulation but the role of the mu opioid receptor in these actions of the drug is not fully characterized. Thus, using mice lacking exon-2 of
Kristin Moksnes et al.
European journal of clinical pharmacology, 68(8), 1147-1156 (2012-03-01)
Our aim was to compare pharmacological aspects of two switching strategies from morphine/oxycodone to methadone; the stop and go (SAG) strategy in which methadone is started directly after the initial opioid has been stopped, and the 3-days switch (3DS), in
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