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Merck
CN

M-019

(+/-)-美沙酮标准液 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C21H27NO
化学文摘社编号:
76-99-3
分子量:
309.45
UNSPSC Code:
41116107
PubChem Substance ID:
329817736
EC Number:
200-659-6
MDL number:
MFCD00056289

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InChI key

USSIQXCVUWKGNF-UHFFFAOYSA-N

InChI

1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3

SMILES string

CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)=O

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal); Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

Gene Information

human ... OPRM1(4988)

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General description

Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine®, Amidone, Methadose®, Physeptone, or Heptadon. This Certified Spiking Solution® is suitable for LC/MS or GC/MS testing methods in pain prescription monitoring, forensic analysis or clinical toxicology.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Dolophine is a registered trademark of Roxane Laboratories, Inc.
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

监管及禁止进口产品
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Philippa Hawley et al.
Pain research & management, 18(2), 83-86 (2013-05-11)
Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use.
The lethal burden of drug overdose.
Lancet (London, England), 382(9895), 833-833 (2013-09-10)
Advice on methadone and oral health: dental public health in action.
C M Jones et al.
Community dental health, 30(2), 68-70 (2013-07-31)
Kobra Lashkaripour et al.
JPMA. The Journal of the Pakistan Medical Association, 62(10), 1003-1007 (2013-07-23)
To examine the 3-month effect of methadone maintenance treatment (MMT) on quality of life (QOL) of substance-dependent outpatients in Iran. The qausi-experimental study performed at the Oral Maintenance Methadone Treatment Clinic of the Baharan Psychiatric Hospital, a university hospital in
David Kao et al.
Annals of internal medicine, 158(10), 735-740 (2013-05-22)
Long-acting opioids are a leading cause of accidental death in the United States, and methadone is associated with greater mortality rates. Whether this increase is related to the proarrhythmic properties of methadone is unclear. To describe methadone-associated arrhythmia events reported
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