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安全信息

M-005

Supelco

吗啡标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C17H19NO3
CAS号:
57-27-2
分子量:
285.34
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

格式

single component solution

储存温度

−20°C

SMILES字符串

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

InChI key

BQJCRHHNABKAKU-KBQPJGBKSA-N

基因信息

human ... OPRM1(4988)

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相关类别

一般描述

该认证的分析标准品适用于从疼痛处方监测、临床毒理学研究和尿液药物检测到药物研究和法医分析的各种GC/MS或LC/MS应用。

吗啡是一种天然的酚类生物碱，常被用于止痛和抗炎。吗啡以 MS Contin®、Kadian®、Oramorph® 和 Roxanol 等商品名销售，由于其应用广泛、成瘾性高，也是一种常见的滥用消遣性药物。

应用

该认证标准溶液（CRM）还可作如下用途：
  • 使用电化学测定吗啡的差分脉冲伏安法在极低体积溶液中开发水凝胶修饰碳糊电极（HCPE）
  • 结合磁性分子印迹固相萃取（MMISPE）和高效液相色谱（HPLC）进行尿液中吗啡的定量分析
  • 使用基于 Pt 纳米颗粒修饰碳纳米角（CNHs@PtNP）传感器对人体尿液和血清样品中的吗啡和 3,4-亚甲基二氧甲基苯丙胺（MDMA）进行电化学检测与测量
  • 使用稳定性指示高效液相色谱法结合光电二极管阵列检测器同时测定吗啡和散装纳曲酮及其复合固体剂型
  • 通过红外（IR）光谱和透射电子显微镜（TEM）分析柠檬酸盐覆盖金纳米颗粒（AuNP）聚集的差异，进而对人血清和尿液样本中的吗啡和布洛芬进行比色估计

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Kadian is a registered trademark of Actavis Elizabeth LLC
MS Contin is a registered trademark of Purdue Frederick Company
Oramorph is a registered trademark of AAIPharma, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-033

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E-052

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IMPM-005-05

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M-003

吗啡-D3 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-006

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M-017

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M-018

吗啡-3- β-D-葡糖醛酸 溶液, 100 μg/mL in methanol: water ( 50:50(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

M-030

吗啡标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-046

吗啡-6- β-D-葡糖苷酸 溶液, 1.0 mg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

M-085

吗啡-D6标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

吗啡-D6标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-096

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M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

N-006

去甲吗啡 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005S

吗啡标准液 溶液, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

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Thitima Chinachoti et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(5), 589-594 (2013-06-12)
Presently, in Siriraj Hospital, intrathecal morphine is routinely used in spinal anesthesia for postoperative pain control in more than 600 cases per month with doses lower than 0.3 mg. However, the incidence of side effects is high. This retrospective data
A Bilir
Clinical and experimental obstetrics & gynecology, 40(1), 118-121 (2013-06-04)
Pain management has a particular importance after Cesarean section. This study was undertaken in order to document the efficacy and side-effects of epidural morphine instead of patient-controlled analgesia technique used for the control of post-cesarean pain during postoperative 24-48 hours.
In response.
Alain Gorgeat
Anesthesia and analgesia, 116(6), 1391-1391 (2013-07-12)
Beatrice Setnik et al.
Journal of opioid management, 9(2), 139-150 (2013-05-28)
To evaluate whether intact or crushed doses of an extended-release formulation of morphine sulfate surrounding an inner core of sequestered naltrexone (MSN) induces signs and symptoms of withdrawal in opioid-dependent patients. Randomized, double-blind, two-way crossover study. Single center. Fourteen patients
D I Peregud et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(3), 3-6 (2013-06-19)
This study was aimed at evaluating the role of nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) cascade in mechanisms of morphine dependency formation. Morphine was introduced by intraperitoneal (i.p.) injections in rats twice per day over six days in doses increasing
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