等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in acetonitrile: water (1:1)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
格式
single component solution
储存温度
−20°C
SMILES字符串
Oc1ccc2C[C@@H]3[C@]4(O)CCC(=O)[C@@H]5Oc1c2[C@]45CC[N@@+]3([O-])CC=C
InChI
1S/C19H21NO5/c1-2-8-20(24)9-7-18-15-11-3-4-12(21)16(15)25-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-,20?/m1/s1
InChI key
GAUIBVINJLVYRY-QBFPIVRFSA-N
一般描述
Naloxone N-oxide is an impurity in pharmaceutical drug formulations of naloxone as well as a potential naloxone urinary metabolite. This certified solution standard is suitable for numerous LC or LC/MS applications from pharmaceutical testing and research to clinical toxicology or forensic analysis. Naloxone, sold under various trade names including Narcan®, Nalone, and Narcanti, is an opiate drug used to counter the effects of opiate overdose such as those involving heroin or morphine.
应用
- Nociceptive Descending Inhibition Restoration: Naloxone N-oxide has been studied in the context of traumatic brain injury in rats, focusing on its role in restoring nociceptive descending inhibition through the periaqueductal gray. This application contributes to our understanding of opioid receptor antagonist research in the recovery of neurological functions (Irvine et al., 2024).
- Opioid Receptor Research: Research on Naloxone N-oxide involves exploring its interaction with opioid receptors, particularly in the context of stress-induced reinstatement of drug preferences. This underscores its importance in studies related to opioid receptor antagonist mechanisms in addiction and stress response (Nygard et al., 2016).
- Quantitative Biochemical Assays: The use of Naloxone N-oxide in liquid chromatography-tandem mass spectrometry assays exemplifies its role in the simultaneous quantification of buprenorphine, naloxone, and their metabolites. This is crucial for pharmacokinetic analysis and monitoring drug metabolism in clinical settings (Swortwood et al., 2016).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Narcan is a registered trademark of Endo Pharmaceuticals Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
55.4 °F
闪点(°C)
13 °C
法规信息
危险化学品
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