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安全信息

H-089

Supelco

1α,25-二羟基维生素D3标准液 CRM 溶液

5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C27H44O3
CAS号:
32222-06-3
分子量:
416.64
EC 号:
200-578-6
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

5 μg/mL in ethanol

应用

clinical testing
clinical testing
clinical testing

包装形式

single component solution

储存温度

−70°C

SMILES字符串

CC(CCCC(C)(C)O)C1CCC2C(\CCCC12C)=C\C=C3\CC(O)CC(O)C3=C

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-

InChI key

GMRQFYUYWCNGIN-KWJBEKLWSA-N

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相关类别

一般描述

1,α25-二羟基维生素D3是在钙吸收和沉积过程中维生素D3的生物活性形式。它对细胞分化和增殖有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α25-二羟基维生素D3可作为化学预防剂抵抗包括前列腺癌和结肠癌在内的多种恶性肿瘤，并显示出了与其他抗癌化合物的协同作用。
一种认证加标溶液®适用于在研究及临床环境下关键定量应用，包括：用于LC/UV及LC-MS/MS维生素D检测的对照和校准品制备；作为系统调节/适用性标准品；线性度验证；内部效能测试；OEM用于制备试剂、检测体系开发以及仪器IQ/OQ。这种稳定的定量溶液形式可为用户提供了显著的好处，包括节省材料、提高劳动效率以及使用的便捷性。保存稳定的Snap-N-Spike®形式可帮助实验室免去痛苦的称重操作，并能在使用前将已知浓度的分析物加入到所选择的基质中。

应用

1,25-二羟基维生素D3可用作认证参考物质，用于通过液相色谱-串联质谱测定生物体液中的分析物。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险声明

H225,H319

危险分类

Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 1

闪点(°F)

57.2 °F - closed cup

闪点(°C)

14 °C - closed cup

法规信息

危险化学品

分析证书(COA)

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Determination of 1, 25-dihydroxyvitamin D2 and 1, 25-dihydroxyvitamin D3 in human serum using liquid chromatography with tandem mass spectrometry
Fang H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1027, 19-26 (2016)
Sensitive analysis of 1?, 25-dihydroxyvitamin D3 in biological fluids by liquid chromatography--tandem mass spectrometry
Kissmeyer AM and Sonne K
Journal of Chromatography A, 935(1-2), 93-103 (2001)
Zhican Wang et al.
Analytical biochemistry, 418(1), 126-133 (2011-07-26)
Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on health and disease. To that end, we have developed a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Nicola Napoli et al.
PloS one, 8(2), e56488-e56488 (2013-02-26)
Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and
R Volchenkov et al.
Scandinavian journal of immunology, 77(4), 246-254 (2013-02-28)
Dendritic cells (DC) are professional antigen-presenting cells that are capable of both activating immune responses and inducing tolerance. Several studies have revealed efficiency of therapeutic vaccination with tolerogenic DC (tolDC) in inhibition of experimental autoimmunity. The purpose of this study
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