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F-013

Supelco

芬太尼标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C22H28N2O
CAS号:
437-38-7
分子量:
336.47
MDL编号:
MFCD00661055
UNSPSC代码:
41116107
PubChem化学物质编号:
329799631
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

包装形式

single component solution

储存温度

−20°C

SMILES字符串

CCC(=O)N(C1CCN(CC1)CCc2ccccc2)c3ccccc3

InChI

1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3

InChI key

PJMPHNIQZUBGLI-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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相关类别

一般描述

该认证的溶液标准适用于各种 LC/MS 或 GC/MS 测试应用，包括从法医分析、临床毒理学和止痛处方监测到尿液药物测试和药物研究。

芬太尼属于合成阿片类药物，具有强效的μ-阿片受体激动作用。它以麻醉和镇痛特性而闻名，效力是海洛因的 100 倍。芬太尼以 Duragesic®、Actiq®和Fentora® 等各种商品名出售，在镇痛活性方面比吗啡更有效。

应用

该认证标准溶液（CRM）还可作如下用途：
  • 使用基于液相色谱-串联质谱（LC-MS/MS）的程序对头发样品中芬太尼及其衍生物进行多残留分析
  • 采用高效液相色谱与二极管阵列检测和安培检测的组合分别和同时测定街头检获样品中的海洛因、芬太尼及其 10 种类似物
  • 开发超高效液相色谱-串联质谱（UHPLC-MS/MS）技术来估算头发样品中的 31 种芬太尼类似物和 6 种合成阿片类药物
  • 通过液-液萃取后的液相色谱-串联质谱（LC-MS/MS）对芬太尼及其类似物和合成阿片类药物全血样品进行分离和定量分析
  • 通过纸喷雾-质谱法对尿液和镇痛片浆液中的芬太尼和去芬太尼含量进行半定量分析

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

Actiq is a registered trademark of Anesta Corp.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Duragesic is a registered trademark of Johnson & Johnson
Fentora is a registered trademark of Cima Labs, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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An EMS guide to chronic pain.
Kevin T Collopy et al.
EMS world, 42(7), 59-63 (2013-08-10)
Nele Plock et al.
International journal of clinical pharmacology and therapeutics, 51(6), 495-508 (2013-04-25)
Intranasal Fentanyl Spray (INFS) was developed for the treatment of breakthrough pain (BTP) in cancer patients using a new route of administration. Dose strengths of 50, 100, and 200 μg INFS (Instanyl®) are currently on the market, however, some adult
Esther Encinas et al.
Paediatric drugs, 15(3), 247-257 (2013-05-10)
Fentanyl is a synthetic opioid commonly used as an anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage regimens in this population are often empirically derived from adults on a body weight basis. However, ontogenic maturation
[Pain therapy. Treating pain patients with opioid preparations].
MMW Fortschritte der Medizin, 155(6), 70-71 (2013-05-25)
Hong-Xia Zhu et al.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 33(4), 342-346 (2013-07-04)
To observe the clinical effect of acupoint injection with small dose of fentanyl-droperido mixed liquor at different time stages on labor analgesia, and explore its function mechanism. One hundred and fifty cases of full-term primiparas who were intended to take
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