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安全信息

F-002

Supelco

芬太尼标准液 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C22H28N2O
CAS号:
437-38-7
分子量:
336.47
MDL编号:
MFCD00661055
UNSPSC代码:
41116107
PubChem化学物质编号:
329799618
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

100 μg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

包装形式

single component solution

储存温度

2-8°C

SMILES字符串

CCC(=O)N(C1CCN(CC1)CCc2ccccc2)c3ccccc3

InChI

1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3

InChI key

PJMPHNIQZUBGLI-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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一般描述

一种有效的合成麻醉性止痛药和局麻药，起效快，作用时间短。芬太尼以 Duragesic®、Actiq®和Fentora® 等各种商品名出售，在镇痛活性方面比吗啡更有效。该认证的溶液标准适用于各种LC/MS或GC/MS测试应用，包括从法医分析、临床毒理学和止痛处方监测到尿液药物测试和药物研究。

应用


  • 镇痛效力测定：芬太尼因其显著的阿片受体激动剂特性而被广泛用用于镇痛效力测定，为我们评估新镇痛药在临床前和临床环境中的疗效提供了基准（Chakravartula et al., 2024）。

  • 体外药理学研究：作为高纯度芬太尼分析标准品，了解药物与阿片受体的相互作用及其对神经通路的影响对于体外药理学研究至关重要（Kanashiro et al., 2024）。

  • 药理学研究用化学品供应：柠檬酸芬太尼溶液是药理学研究的重要试剂，特别是对于疼痛管理和阿片类药物成瘾治疗研究更为重要(Lee et al., 2024）。

  • 合成阿片类药物溶液：这种合成阿片类药物可用于科学研究，用于探索更安全、更有效的止痛方法，如患者自控镇痛系统（patient-controlled analgesia system）（Huang et al., 2024).

  • 阿片受体激动剂研究：芬太尼可用于阿片类药物的受体动力学研究，有助于开发针对疼痛和阿片类药物使用障碍的靶向疗法（Xu et al., 2024）。

法律信息

Actiq is a registered trademark of Anesta Corp.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Duragesic is a registered trademark of Johnson & Johnson
Fentora is a registered trademark of Cima Labs, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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[Pain therapy. Treating pain patients with opioid preparations].
MMW Fortschritte der Medizin, 155(6), 70-71 (2013-05-25)
Esther Encinas et al.
Paediatric drugs, 15(3), 247-257 (2013-05-10)
Fentanyl is a synthetic opioid commonly used as an anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage regimens in this population are often empirically derived from adults on a body weight basis. However, ontogenic maturation
Terry J Kreeger et al.
Journal of wildlife diseases, 49(3), 674-678 (2013-06-20)
Seven grizzly (Ursus arctos; four male, three female) and three black (Ursus americanus; two male, one female) bears caught in culvert traps or leg snares were immobilized in northwestern Wyoming with carfentanil and xylazine at doses, respectively, of 0.011 ±
M Iu Kurochkin
Klinichna khirurhiia, (6)(6), 66-68 (2013-08-31)
In 45 newborns, operated on for the inborn failures of gut, the markers of stress and indices of central hemodynamics were studied up. General anaesthesia was applied together with caudal-epidural injection of local anaesthetics in 15 newborns, in 15--the adjuvants--klophelline
Elzbieta P Wala et al.
Journal of opioid management, 9(2), 85-96 (2013-05-28)
Opioids may cause progressive enhancement of pain sensitivity (opioid-induced hyperalgesia [OIH]) and thus, exacerbate existing pain. Animal studies also demonstrate paradoxical OIH with an ultralow dose (ULD, subanalgesic) of opioid; eg, the μ-opioid, morphine. Repeated administration of ULD-morphine resulted in
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