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D-073

Supelco

5α-二氢睾酮(DHT)标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

别名:

5 α-二氢睾丸激素 溶液, 5-α-二氢睾丸激素, DHT, 二氢睾酮, 5α−DHT 溶液

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About This Item

经验公式（希尔记法）:
C19H30O2
CAS号:
521-18-6
分子量:
290.44
MDL编号:
MFCD00003667
UNSPSC代码:
41116107
PubChem化学物质编号:
329798632
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing
clinical testing

格式

single component solution

储存温度

−70°C

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1

InChI key

NVKAWKQGWWIWPM-ABEVXSGRSA-N

相关类别

一般描述

该认证加标溶液®适用于从临床和诊断测试和内分泌学到运动测试的各种 GC/MS 和 LC/MS 应用。

5α-二氢睾酮（DHT）是一种类固醇激素，是天然雄激素睾酮的代谢物，通过 NADPH 依赖性酶 5α-还原酶的作用形成。它涉及广泛的疾病，例如男性秃发、良性前列腺增生、以及前列腺癌等。作为合成代谢类固醇，DHT也被用作性能增强药物，以促进肌肉生长。

应用

该认证标准物质（CRM）还可作如下用途：
  • 使用台式气相色谱-质谱联用法（GC-MS）同时分析人血清样品中的睾酮和 5α-二氢睾酮
  • 通过液相色谱-电喷雾电离-串联质谱法（LC/ESI-MS/MS）测定睾酮和 5α-二氢睾酮在吡啶酸及其类似物的质子亲和衍生反应中的含量
  • 通过气相色谱-串联质谱法（GC-MS/MS）测定黑头鲦鱼血浆和睾丸样品中的睾酮和 5α-二氢睾酮
  • 根据世界反兴奋剂机构（WADA）的要求，采用高分辨率全扫描-电喷雾-液相色谱（HR-FS-ESI-LC）结合四极轨道阱质谱（Q/Orbitrap MS）对尿样中表睾酮、睾酮、5α-二氢睾酮、去氢表雄酮、雄酮和乙胆甾醇酮进行多残留筛选。
  • 通过稳定同位素稀释液相色谱-电喷雾电离-串联质谱法（SID-LC-ESI-MS/MS）对使用吡啶甲酸进行衍生化后的 9 种羟基雄激素及其偶联物进行定量分析

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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T-037

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T-046

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

危险化学品

分析证书(COA)

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Julia Johansson et al.
PloS one, 8(1), e54357-e54357 (2013-01-26)
In rats with dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), repeated low-frequency electrical stimulation of acupuncture needles restores whole-body insulin sensitivity measured by euglycemic hyperinsulinemic clamp. We hypothesized that electrical stimulation causing muscle contractions and manual stimulation causing needle sensation have
Angel On Kei Chan et al.
Clinical chemistry, 59(5), 798-806 (2013-03-21)
5α-Reductase 2 deficiency (5ARD) is a known cause of 46,XY disorders of sex development (DSD). Traditionally, the diagnosis relies on dihydrotestosterone (DHT) measurement, but the results are often equivocal, potentially leading to misdiagnosis. We reviewed alternative approaches for diagnosis of
Paula M Marchetti et al.
Annals of clinical biochemistry, 50(Pt 2), 95-107 (2013-02-23)
Dihydrotestosterone (DHT) is the most potent natural androgen in humans. There has been an increasing interest in this androgen and its role in the development of primary and secondary sexual characteristics as well as its potential roles in diseases ranging
Changmeng Cai et al.
The Journal of clinical investigation, 123(3), 1109-1122 (2013-02-22)
Fusion of the androgen receptor-regulated (AR-regulated) TMPRSS2 gene with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression of ERG, an ETS transcription factor, but critical downstream effectors of ERG-mediating PCa development remain to be established. Expression of the SOX9 transcription
Francesca Argellati et al.
Anticancer research, 33(3), 815-820 (2013-03-14)
To investigate periostin (POSTN) expression in the LNCaP cell line. Our LNCaP strain did not constitutively express the POSTN gene. Through cell transfection with a cloning vector, we developed an LNCaP cell line that stably expressed POSTN. LNCaP wild-type and
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