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等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
Cl.[2H]C([2H])([2H])NCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI
1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1/i1D3;
InChI key
BFFSMCNJSOPUAY-HQKLNPQUSA-N
一般描述
A stable-labeled internal standard suitable for numerous GC/MS and LC/MS applications from clinical toxicology and urine drug testing to forensic analysis and isotope dilution methods. Duloxetine, marketed in the US under the trade name Cymbalta®, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and to alleviate pain associated with diabetic neuropathy, fibromyalgia, and osteoarthritis.
应用
- Rapid Structure-Based Screening for COVID-19: Duloxetine-D₃ hydrochloride solution plays a key role in rapid structure-based screening, potentially informing the development of therapeutic agents for COVID-19 due to its properties as a serotonin-norepinephrine reuptake inhibitor, crucial for high-impact pharmaceutical research (Yang et al., 2020).
- UV-Triggered Drug Release: The high-purity Duloxetine-D₃ solution enhances UV-triggered drug release studies from mesoporous titanium nanoparticles loaded with pharmaceutical agents, indicating significant benefits for developing controlled drug delivery systems in biotechnological applications (Zuo et al., 2024).
- Antioxidant Activity and Eczema Treatment: Duloxetine-D₃ HCl serves as an internal standard in studies evaluating the antioxidant activities and therapeutic applications of drug-loaded liposomes for eczema treatment, highlighting its role in enhancing bioanalytical assay development (Shen et al., 2024).
- Synthesis and Application of EGFR Inhibitors for Cancer: As a stable isotope-labeled compound, Duloxetine-D₃ hydrochloride is used in the synthesis and clinical application studies of small-molecule EGFR inhibitors, underlining its critical application in cancer therapy research (Wang et al., 2024).
- Nanoparticle Drug Release Behaviors: The solution′s role in studying poly(lactic-co-glycolic acid) nanoparticles highlights its utility in pharmaceutical-grade calibration for analyzing hydrophilic and hydrophobic drug release behaviors, essential for pharmaceutical and biomedical research (Wang et al., 2024).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Cymbalta is a registered trademark of Eli Lilly and Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
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