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安全信息

D-063

Supelco

脱氢表雄酮（DHEA）标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

别名:

去氢表雄酮

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About This Item

经验公式（希尔记法）:
C19H28O2
CAS号:
53-43-0
分子量:
288.42
EC 号:
200-659-6
MDL编号:
MFCD00063622
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChI key

FMGSKLZLMKYGDP-USOAJAOKSA-N

相关类别

一般描述

脱氢表雄酮（DHEA）是一种内源性类固醇，与人类和其他哺乳动物的广泛生物学效应有关。除了根据世界反兴奋剂机构（WADA）的《世界反兴奋剂法典》进行测试外，还测量了DHEA水平，以筛查先天性肾上腺肥大（CAH）的新生儿并确定多囊卵巢综合征和肾上腺肿瘤等雄激素过多的状况。该校准物料适用于从临床和诊断测试、内分泌学到运动测试的GC/MS和LC/MS应用。

应用

  • 至关重要。本研究开发了一种提取和GC-MS分析膳食补充剂中合成代谢类固醇（包括脱氢表雄酮）的方法，目的在于兴奋剂检查应用，提高了脱氢表雄酮检测在运动科学中的可靠性（Dahmani et al., 2018）。
  • 激素分析色谱法：研究人员开发了一种液相色谱-串联质谱法，用于同时测定血清中的睾酮、雄烯二酮和脱氢表雄酮，该研究为研究类固醇激素途径及其在各种生理过程中影响的研究人员提供了一种稳健的工具（Xu et al., 2017）。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Elizabeth Huerta-García et al.
BioMed research international, 2013, 382058-382058 (2013-03-14)
Particulate matter (PM) and nanoparticles (NPs) induce activation and dysfunction of endothelial cells characterized by inhibition of proliferation, increase of adhesion and adhesion molecules expression, increase of ROS production, and death. DHEA has shown anti-inflammatory and antioxidant properties in HUVEC
Marta Kokot-Kierepa et al.
Ginekologia polska, 83(10), 772-777 (2013-02-07)
With increasing longevity in Poland, women can now expect to live around 40% of their lives after menopause, and there is a growing desire for older women to preserve their vitality sexual function and quality of life. The most common
Jean-Pierre Savineau et al.
Biochemical pharmacology, 85(6), 718-726 (2012-12-29)
Dehydroepiandrosterone (DHEA) is a steroid hormone derived from cholesterol synthesized by the adrenal glands. DHEA and its 3β-sulphate ester (DHEA-S) are the most abundant circulating steroid hormones. In human, there is a clear age-related decline in serum DHEA and DHEA-S
Stephanie Wemm et al.
Alcohol (Fayetteville, N.Y.), 47(2), 149-157 (2013-01-22)
Problematic drinking is a widespread problem among college students, and can contribute to alcohol dependence during later adulthood, particularly among females. The current study assessed vulnerability for alcohol-related consequences by comparing self-reported drinking with coping styles and physiological and behavioral
E Borman et al.
Clinical and experimental obstetrics & gynecology, 39(4), 429-431 (2013-03-01)
To determine if in a population of women with diminished oocyte reserve as evidenced by day 3 serum follicle stimulating hormone (FSH) levels > 12 mIU/ml women with lower dehydroepiandrosterone sulfate (DHEA-s) levels produce fewer oocytes or have lower pregnancy
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