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等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
pharmaceutical (small molecule)
格式
single component solution
储存温度
−20°C
SMILES字符串
OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
InChI
1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI key
KBAUFVUYFNWQFM-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
一般描述
Doxylamine is a member of the ethanolamine class of antihistamines and is the most effective over-the-counter (OTC) sedative in the US. This Snap-N-Spike® Reference Solution is applicable to use in LC/MS or GC/MS applications for clinical toxicology or forensic analysis.
应用
- Quality assessment of doxylamine succinate: A chemometric approach was applied for quality assessment of doxylamine succinate with its degradation product, using predictive models based on UV-spectrophotometric data, highlighting its utility in ensuring the integrity of pharmaceutical formulations (Abd El-Hadi et al., 2022).
- Analysis in over-the-counter medications: Doxylamine succinate was analyzed as part of a quaternary mixture in cold medications, utilizing a sequential spectrophotometric resolution approach, indicating its role in multi-component pharmaceutical analysis (Kelani et al., 2023).
- LC-MS/MS method for plasma levels: A sensitive LC-MS/MS method was developed for determining doxylamine levels in human plasma, demonstrating its application in pharmacokinetic studies and bioequivalence assessments (Fu et al., 2022).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
WGK
WGK 2
闪点(°F)
49.5 °F
闪点(°C)
9.7 °C
法规信息
危险化学品
J Y Renault et al.
Toxicology and applied pharmacology, 130(2), 177-187 (1995-02-01)
Inhibition of chondrogenesis in limb bud cell micromass cultures has been proposed as a short-term teratogen detection test. Validation studies were performed by testing large series of reference compounds and comparing their teratogenic potential with their ability to inhibit chondrogenesis;
Ashutosh Pathak et al.
Journal of AOAC International, 91(5), 1059-1069 (2008-11-05)
Three simple, rapid, and accurate methods, i.e., the derivative ratio spectra-zero-crossing method (method I), double divisor-ratio spectra derivative method (method II), and column reversed-phase high-performance liquid chromatographic (RP-HPLC) method (method III) were developed for the simultaneous determination of doxylamine succinate
B S Somashekar et al.
Magnetic resonance in chemistry : MRC, 42(7), 636-640 (2004-06-08)
A protonation and dynamic structural study of doxylamine succinate, a 1:1 salt of succinic acid with dimethyl-[2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethyl]amine, in solution using one- and two-dimensional 1H and 13C NMR experiments at variable temperature and concentration is presented. The two acidic protons of
A E Rudenko et al.
Likars'ka sprava, (2)(2), 55-59 (2003-05-31)
A positive result has been obtained in treating sleep disorders in patients with chronic vascular affections of the brain with using the drugs donormyl and sonnate-KM [symbol: see text]. Donormyl is recommended for use in sleep disturbances (not very prolonged
Andries Pelser et al.
Biopharmaceutics & drug disposition, 23(6), 239-244 (2002-09-06)
The intranasal route of administration provides a potential useful way of administering a range of systemic drugs. In order to assess the feasibility of this approach for the treatment of nausea and vomiting, doxylamine succinate was studied in rats for
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