推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
Cl.CNCCC(Oc1ccc2ccccc2c1)c3cccs3
InChI
1S/C18H19NOS.ClH/c1-19-11-10-17(18-7-4-12-21-18)20-16-9-8-14-5-2-3-6-15(14)13-16;/h2-9,12-13,17,19H,10-11H2,1H3;1H
InChI key
QZIJQNJKJMLFKV-UHFFFAOYSA-N
一般描述
Duloxetine, marketed in the US under the trade name Cymbalta®, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and to alleviate pain associated with diabetic neuropathy, fibromyalgia, and osteoarthritis. This Certified Spiking Solution® is applicable for use in applications such as clinical toxicology, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.
应用
- Duloxetine HCl in Drug Release Studies: A study evaluated the application of bicarbonate buffer dissolution testing with gentle mechanistic stress to predict bioequivalence of enteric-coated pellet formulations including Duloxetine HCl, emphasizing its importance in CNS pharmacology and pharmaceutical quality control (Ikuta et al., 2024).
- Nanovesicle Formulation of Duloxetine: Research explored the formulation and optimization of ultra-elastic nanovesicles loaded with Duloxetine HCl, aimed at enhancing the antidepressant effect through intranasal and transdermal delivery. This approach provides insights into advanced drug delivery systems for CNS pharmacology and neurotransmitter research (Abd-Elal et al., 2023).
- Pharmacokinetics and Pharmacodynamics: An investigation into chitosan-grafted PLGA nanoparticles aimed to boost the pharmacokinetic and pharmacodynamic effect of Duloxetine HCl using Box-Benkhen Design, contributing to the understanding of its bioavailability and therapeutic efficacy in biochemical research on antidepressants (Salem et al., 2023).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cymbalta is a registered trademark of Eli Lilly and Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Long Ma et al.
Neural regeneration research, 16(10), 2093-2098 (2021-03-02)
After spinal cord injury, the upward conduction of the spinal cord is lost, resulting in the loss of micturition control, which manifests as detrusor sphincter dyssynergia and insufficient micturition. Studies have shown that serotonergic axons play important roles in the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门