推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
pharmaceutical (small molecule)
包装形式
single component solution
储存温度
−20°C
SMILES字符串
OC(CO[N+]([O-])=O)CO[N+]([O-])=O
InChI
1S/C3H6N2O7/c6-3(1-11-4(7)8)2-12-5(9)10/h3,6H,1-2H2
InChI key
ASIGVDLTBLZXNC-UHFFFAOYSA-N
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一般描述
1，3-二硝基甘油是药物血管扩张剂硝酸甘油的主要血浆代谢产物。该经认证的加标溶液®适用于药学研究或临床毒理学中基于色谱或质谱的应用。硝酸甘油用于治疗心脏病，例如心绞痛和慢性心力衰竭。
应用
- 单次24小时施用硝酸甘油透皮基质递送系统后硝酸甘油及其两种代谢物的群体药代动力学：本研究对硝酸甘油的群体药代动力学进行了全面分析，重点研究了其行为及其代谢物在使用透皮给药系统后的行为。这些发现有助于我们了解此类系统中硝酸甘油的系统可用性和作用，考虑到其结构和功能的相似性，这可能与1,3-二硝基甘油有关（Auclair et al., 1998）。
- 硝酸甘油经皮给药的新药代动力学建模：本研究探索了先进的药代动力学模型，该模型描述了硝酸甘油通过透皮贴剂给药时的吸收和作用。此类模型对于用于类似化合物（如1,3-二硝基甘油）的有效透皮给药系统的开发至关重要（Auclair et al., 1998）。
- 两种药物在粘合性透皮硝酸甘油贴剂中的生物等效性比较：本研究比较了两种硝酸甘油透皮贴剂的生物等效性，重点介绍了透皮系统设计和性能的关键因素，这些因素可能同样适用于1,3-二硝基甘油（Harrison et al., 1996）。
- 1,3-二硝基甘油的经皮吸收和药代动力学分析试验：本研究与1,3-二硝基甘油直接相关，考察了其经皮吸收特性，为其在经皮给药系统中的潜在应用提供了见解（Ogiso et al., 1990）。
- 含谷胱甘肽和无机亚硝酸盐溶液的分析：在硝化甘油代谢研究中的应用：这项分析虽然主要关注硝酸甘油，但是也可以为1,3-二硝基甘油与谷胱甘肽等生物分子的代谢途径和相互作用提供次要见解，这对我们理解其药理作用至关重要（Curry et al., 1987）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
危险化学品
Ivan S de la Lande et al.
European journal of pharmacology, 486(2), 201-207 (2004-02-21)
The influence of the endothelium on glyceryl trinitrate metabolism and relaxation and the relationship to tolerance induced by transdermal glyceryl trinitrate was explored in rat aorta. Metabolism was assessed in artery segments incubated with glyceryl trinitrate (1.0 microM) for 2
H R Kwon et al.
Biopharmaceutics & drug disposition, 13(2), 141-152 (1992-03-01)
Nitroglycerin was administered to eight healthy volunteers in the form of sublingual tablets, oral sustained-release tablets, and an oral solution. Blood samples were collected for measurement of nitroglycerin and its two isomeric glyceryl dinitrate metabolites. Blood pressure and pulse rate
Magnus Petersson et al.
Clinical physiology and functional imaging, 28(4), 229-234 (2008-04-04)
Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation of GTN have been characterized; a high-affinity pathway
N Higo et al.
Pharmaceutical research, 9(2), 187-190 (1992-02-01)
The metabolism of nitroglycerin (GTN) to 1,2- and 1,3-glyceryl dinitrate (GDN) by hairless mouse skin in vitro has been measured. In the first set of experiments, GTN was incubated with the 9000g supernatant of fresh, homogenized tissue in the presence
F W Lee et al.
Journal of pharmacokinetics and biopharmaceutics, 21(5), 533-550 (1993-10-01)
Intravenous infusions of nitroglycerin (GTN), 1,2-glyceryl dinitrate (1,2-GDN), and 1,3-glyceryl dinitrate (1,3-GDN) were given to four conscious dogs at 10 micrograms/min, 30 micrograms/min, 50 micrograms/min, and 70 micrograms/min of GTN and 20 micrograms/min and 100 micrograms/min of GDNs. The steady
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