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C-117

Supelco

皮质酮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C21H30O4
CAS号:
50-22-6
分子量:
346.46
MDL编号:
MFCD00037715
UNSPSC代码:
41116107
PubChem化学物质编号:
329774873
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing
clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

相关类别

一般描述

皮质酮是在肾上腺中产生的皮质类固醇和醛固酮前体。通过LC-MS/MS测量血清皮质酮水平，以筛查新生儿和诊断11-羟化酶缺乏症。

应用


  • 用于应激激素研究的皮质脂酮ELISA试剂盒：研究表明了皮质脂酮ELISA试剂盒在测定应激激素水平方面的功效，该研究对肾上腺功能和应激相关疾病的研究做出了重大贡献。该应用对于体内皮质脂酮分析至关重要，可以让我们详细地监测面对各种压力源激素产生的波动 (Ornelas et al., 2024）。

  • 用于受体结合测定的高纯度皮质脂酮：皮质脂酮溶液被广泛用于受体结合测定，用于了解皮质类固醇受体的相互作用。这些研究对于增进我们内分泌学生化研究的知识至关重要，对我们探索皮质类固醇途径及其在体内的作用尤其重要（Xie et al., 2024）。

  • 用于内分泌研究的合成皮质脂酮溶液：合成皮质脂酮可用于临床实验装置，用于考察受控条件下内分泌系统的反应。在内分泌系统对外部压力因素的适应及其对整体生理健康影响的研究中，这种应用尤其明显（Costa et al., 2024）。

  • 用于应激反应研究的液体皮质脂酮：皮质脂酮液体制剂对于应激反应研究十分重要，为研究其对动物行为和生理反应的急性和慢性影响提供了一种一致、可测量的方法（Ornelas et al., 2023）。

  • 用于糖皮质激素受体实验的皮质脂酮试剂皮质酮是糖皮质激素受体实验中不可或缺的试剂，这些实验对于我们理解糖皮质激素受体动力学及其在各种生理过程（包括免疫反应和代谢调节）的影响必不可少 （Heraudeau et al., 2023）。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

储存分类代码

3 - Flammable liquids

WGK

WGK 1

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

危险化学品

分析证书(COA)

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N E Ordian et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 280-289 (2013-07-23)
Anxious-depressive state was studied in experimental "stress-restress" model of posttraumatic stress disorder (PTSD) using adult rat males. Rat males were born by control females and whose mothers were under 60-minute immobilization stress since 15 until 19 days of pregnancy. Then
T Shavlakadze et al.
American journal of physiology. Cell physiology, 305(1), C26-C35 (2013-04-19)
Circadian rhythms and metabolism are tightly integrated, and rhythmic expression of metabolic factors is common in homeostatic processes. We measured the temporal changes in the expression of myogenic regulatory factors and expression and activity level of molecules involved in protein
L J F van de Ven et al.
Poultry science, 92(4), 1050-1061 (2013-03-09)
Little is known about physiological responses of early- versus late-hatching chicks to early posthatch conditions in broiler practice. We investigated effects of hatching time on perinatal broiler physiology in 2 hatching systems, differing in conditions: a conventional hatcher, where chicks
T V Shemenkova et al.
Bulletin of experimental biology and medicine, 154(4), 464-466 (2013-03-15)
ACTH1-24(1 mg/kg) administered to 5-7-day-old rats reduced their locomotor activity and did not alter blood levels of corticosterone. ACTH administration on postnatal days 12-14 increased corticosterone levels, but had no effect on locomotor activity. Thus, the behavioral effect of ACTH
Atish Mukherji et al.
Cell, 153(4), 812-827 (2013-05-15)
Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic
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实验方案

LC/MS/MS Analysis of Steroid Hormones in Plasma

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

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