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等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol (as free base)
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
Clc1cc2c(cc1)CCc3c(cccc3)N2CCCN(C([2H])([2H])[2H])C.Cl
InChI
1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H/i1D3;
InChI key
WIMWMKZEIBHDTH-NIIDSAIPSA-N
一般描述
Clomipramine is a tricyclic antidepressant used to many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This internal standard is is suitable for quantitation of Clomipramine levels in urine, serum, or plasma by LC/MS or GC/MS for applications in clinical toxicology, forensic analysis, isotope dilution methods, or pharmaceutical research.
应用
- Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression.: This study investigates the metabolic profiles in the brain following different administration routes of clomipramine in a rat model of depression, providing insights into its pharmacokinetics and pharmacodynamics (Abramova et al., 2021).
- Serotonergic regulation of the buccal (feeding) rhythm of the pond snail, Lymnaea stagnalis. An immunocytochemical, biochemical and pharmacological approach.: This research explores the serotonergic regulation in pond snails, employing clomipramine to understand its role in modulating neural rhythms, which has implications for understanding neurotransmitter systems (Elekes et al., 2018).
- Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression.: This study uses proteomic techniques to investigate changes in the prefrontal cortex of rats treated with clomipramine, contributing to the understanding of its impact on brain protein expression in depressive states (Gellén et al., 2017).
- A qualitative method for prediction of amine oxidation in methanol and water.: The paper presents a method for predicting amine oxidation, utilizing clomipramine as a case study, highlighting its importance in understanding chemical stability in various solvents (Bäcktorp et al., 2015).
- Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.: This research identifies potential biomarkers for drug-induced hepatic phospholipidosis, with clomipramine used to validate the biomarkers, aiding in the development of safer pharmaceuticals (Saito et al., 2014).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Luiza G Tunes et al.
ACS infectious diseases, 6(5), 1121-1139 (2020-04-15)
The drugs currently used to treat leishmaniases have limitations concerning cost, efficacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against L. infantum and L. braziliensis intracellular amastigotes with IC50 values ranging
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