等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
[2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D
InChI key
JYGXADMDTFJGBT-BJJKTIQHSA-N
一般描述
皮质醇-D4 (9,11,12, 12-D4) 是糖皮质激素皮质醇的氘化形式。这种稳定的标记内标适用于通过LC-MS / MS对新生儿先天性肾上腺皮质增生（CAH）筛查和血清或血浆中的皮质醇水平进行定量，通过LC-MS / MS测定包括库欣综合征、艾迪生病和希恩氏综合症在内的多种疾病 。
应用
该认证加标溶液® 适用于从临床和诊断测试和内分泌学到运动测试的各种 GC/MS 和 LC/MS 应用。该认证标准物质（CRM）还可作如下用途：
- 在通过高效液相色谱-串联质谱（HPLC-MS/MS）分析人体汗液样品中的皮质醇期间，通过大气压化学电离（APCI）和选择性反应监测（SRM）鉴定皮质醇
- 通过液相色谱-串联质谱（LC-MS/MS）联合测定 48 份血清样品中的皮质醇和可的松
- 开发和验证 LC-MS/MS 方法，测定尿液样本中五种类固醇―游离皮质醇、可的松、四氢皮质醇、异丙四氢皮质醇和四氢可的松
- 通过液相色谱-电喷雾-串联质谱（LC-MS/MS）对 103 份头发样品中的皮质醇、可的松和硫酸脱氢表雄酮（DHEAS）进行多残留分析
- 使用简单的蛋白质沉淀技术进行样品制备，通过 LC-MS/MS 快速分析超过一年的 2860 个血清样品的皮质醇
特点和优势
- 完全符合 ISO/IEC 17025 和 ISO 17034 认证
- 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
- 通过实时稳定性研究严格测试，以确保准确性和保质期
- 使用合格的精密天平进行重量准备，以确保最小不确定性
- 氩气环境下火焰密封，装入安瓿以便长期保存
- 提供方便的 DEA 豁免格式，以提高实验室效率
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
危险化学品
Juan P Sanabria-Mazo et al.
BMJ open, 10(7), e038107-e038107 (2020-07-28)
The IMPACT study focuses on chronic low back pain (CLBP) and depression symptoms, a prevalent and complex problem that represents a challenge for health professionals. Acceptance and Commitment Therapy (ACT) and Brief Behavioural Activation Treatment for Depression (BATD) are effective
Measurement in saliva from neurotypical adults of biomarkers pertinent to autism spectrum disorders.
Helen V Ratajczak et al.
Future science OA, 1(4), FSO70-FSO70 (2016-12-30)
Measure biomarkers pertinent to autism in saliva from humans. At 7:30 PM (reading instructions) and 8:30 PM (hearing instructions), neurotypical adults (6 M, 6 F) each spat into tubes containing protease inhibitors. Cells were counted, samples aliquoted, frozen and thawed.
X Yang et al.
Cell death & disease, 5, e1308-e1308 (2014-06-27)
Chronic psychological stress has been demonstrated to play an important role in several severe diseases, but whether it affects disease therapy or not remains unclear. Mesenchymal stem cells (MSCs) have been demonstrated to have therapeutic potentials in treating tissue injury
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