推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
SNAP-N-SPIKE®, SNAP-N-SHOOT®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CN1C(CCC1=O)c2cccnc2
InChI
1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChI key
UIKROCXWUNQSPJ-VIFPVBQESA-N
一般描述
尼古丁主要尿代谢物的分析标准品。可替宁不仅是尼古丁产品（包括香烟，雪茄和鼻烟）使用者的生物标志物，而且′还是烟草中的生物碱。该分析标准品的适当用途包括作为GC/MS和LC/MS应用校准品和对照品的起始材料，用于尼古丁检测方法或尼古丁生物标志物的临床和诊断试验。
应用
- 医学研究中的生物标志物分析: 考察了脯氨酸肽酶作为与吸烟相关的炎症潜在指标，其中的（-）-可替宁是一种关键的生物标志物，该研究可以加深我们对吸烟者慢性炎症及其生化途径的理解（Yıldırım & Kulaksızoglu, 2024).
- 比较毒理学研究：研究评估了加热烟草制品使用者中的血液炎症生物标志物，将这些标志物（包括（-）-可替宁）与非吸烟者进行了比较，提供了有关新烟草制品的使用对炎症影响的见解（Świątkowska et al., 2024）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Cotinine as a biomarker of environmental tobacco smoke exposure.
N L Benowitz
Epidemiologic reviews, 18(2), 188-204 (1996-01-01)
Sarah Connor Gorber et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 11(1), 12-24 (2009-02-28)
Smoking is a leading cause of premature mortality and preventable morbidity. Surveillance is most often based on self-reported data, but studies have shown that self-reports tend to underestimate smoking status. This study systematically reviewed the literature to measure the concordance
V Haufroid et al.
International archives of occupational and environmental health, 71(3), 162-168 (1998-05-20)
A minireview is presented concerning the use of cotinine as a tobacco-smoke exposure index. First, general considerations about methods for the determination of urinary cotinine are presented. Besides pure analytical aspects, this minireview considers major problems encountered in the establishment
Natalie S Shenker et al.
Epidemiology (Cambridge, Mass.), 24(5), 712-716 (2013-07-23)
Most biomarkers of exposure tend to have short half-lives. This includes cotinine, a metabolite of nicotine widely used to assess smoke exposure. Cotinine is thus unsuitable as a determinant of past exposure to cigarette smoke. We used bisulphite pyrosequencing of
R R Watts et al.
Environmental health perspectives, 84, 173-182 (1990-03-01)
A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the U.S. Environmental
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