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安全信息

C-006

Supelco

可待因标准液 溶液

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C18H21NO3
CAS号:
76-57-3
分子量:
299.36
EC 号:
200-659-6
MDL编号:
MFCD06764379
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

浓度

1 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

包装形式

single component solution

储存温度

−20°C

SMILES字符串

COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI

1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

InChI key

OROGSEYTTFOCAN-DNJOTXNNSA-N

基因信息

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)

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一般描述

可待因是一种具有镇痛、镇咳和镇静作用的鸦片制剂，是鸦片中第二大主要生物碱。此认证参考溶液作为校准物或对照品中的起始材料，用于临床毒理学、法医分析、制药研究和止痛处方监测等的各种LC/MS或GC/MS检验方法。作为一种广泛流行的消遣性药物，可待因在澳大利亚、新西兰、罗马尼亚、瑞典和美国等国家受到了多种麻醉品管制法的监管。由于鸦片被归类为受控物质，Cerrilliant都是以免DEA溶液的形式提供绝大多数鸦片参考标准品的，这带来了更高的便利性。

应用


  • Codeine Solution in Opioid Receptor Studies: A recent review discusses the phytochemical and nutritional composition of Papaver plants, known for containing codeine. It outlines the plant′s biotechnological applications, potentially relevant for opioid receptor studies, and can be a basis for developing high-purity codeine solutions for research purposes. This highlights codeine′s role in biochemical research, especially in studying analgesic mechanisms and opioid receptor pharmacology (Butnariu et al., 2022).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

51.8 °F - closed cup

闪点(°C)

11.0 °C - closed cup

法规信息

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分析证书(COA)

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K Krause et al.
Allergy, 68(2), 256-258 (2013-01-17)
Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF-induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct? Wheal and flare responses
Mladen V Tzvetkov et al.
Biochemical pharmacology, 86(5), 666-678 (2013-07-10)
We investigated whether morphine and its pro-drug codeine are substrates of the highly genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms may affect morphine and codeine pharmacokinetics in humans. Morphine showed low transporter-independent membrane permeability (0.5 × 10⁻⁶
Rajeev Subramanyam et al.
International journal of pediatric otorhinolaryngology, 77(2), 194-199 (2012-11-20)
Although commonly performed, pediatric tonsillectomy is not necessarily a low risk procedure due to potentially life threatening perioperative complications. There is paucity of literature on lethal anesthesia and surgical complications of tonsillectomy. In this article, we have reviewed both minor
Is it farewell to codeine?
Brian J Anderson
Archives of disease in childhood, 98(12), 986-988 (2013-08-27)
Laurence Toms et al.
The Cochrane database of systematic reviews, (1)(1), CD001547-CD001547 (2009-01-23)
This is an updated version of the Cochrane review published in Issue 4, 1998. Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve
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