推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
Clc1c(c(c(c(c1[2H])[2H])C(CN)CC(=O)O)[2H])[2H]
InChI
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/i1D,2D,3D,4D
InChI key
KPYSYYIEGFHWSV-RHQRLBAQSA-N
一般描述
Baclofen, a derivative of gamma-aminobutyric acid (GABA), is a muscle relaxant used to treat spasticity. Marketed with brand names such as Kemstro, Lioresal or Gablofen, the drug has also shown effectiveness in the treatment of alcoholism. This certified solution standard is suitable for use as an internal standard in quantitative mass spectrometry-based testing applications in clinical toxicology, forensic analysis, pharmaceutical research or diagnostic testing.
应用
- Antidepressant Efficacy in Psychotherapy: Analyzes the effectiveness of combining antidepressants like O-Desmethylvenlafaxine with psychotherapy, enhancing therapeutic strategies for depression treatment (Alemi et al., 2024).
- Advanced Quantification Methods: Development of a multiplexed liquid chromatography-tandem mass spectrometry method for the quantification of Venlafaxine and its metabolites, including O-Desmethylvenlafaxine, crucial for precise pharmacokinetic studies in clinical settings (Pandey et al., 2024).
- Pharmacokinetic Modeling: Utilizes physiologically based pharmacokinetic modeling to explore the impact of CYP2D6 and CYP2C19 polymorphisms on Venlafaxine metabolism, crucial for understanding the role of O-Desmethylvenlafaxine in therapeutic efficacy and drug-gene interactions (Shen et al., 2024).
- Impact of Pharmacogenomics: Studies the influence of CYP2D6 phenotype on the pharmacokinetics of Venlafaxine in elderly patients, highlighting the importance of O-Desmethylvenlafaxine levels in optimizing antidepressant dosing (Men et al., 2024).
- Environmental Monitoring: Investigates the presence of pharmaceuticals, including O-Desmethylvenlafaxine, in surface waters under the EU Water Framework Directive, emphasizing the need for robust environmental surveillance and pollution control measures (Colzani et al., 2024).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
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