推荐产品
等级
certified reference material
质量水平
形式
liquid
特点
SNAP-N-SPIKE®, SNAP-N-SHOOT®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
drug control
Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
浓度
100 μg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
格式
single component solution
质量偏移
M+3
运输
wet ice
储存温度
−20°C
SMILES字符串
[2H]C([2H])([2H])N1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)c3ccccc3)C(O)=O
InChI
1S/C16H19NO4/c1-17-11-7-8-12(17)14(15(18)19)13(9-11)21-16(20)10-5-3-2-4-6-10/h2-6,11-14H,7-9H2,1H3,(H,18,19)/t11-,12+,13-,14+/m0/s1/i1D3
InChI key
GVGYEFKIHJTNQZ-GZBWLTEMSA-N
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一般描述
一种稳定标记的内参，适用于同位素稀释方法或通过GC/MS或LC/MS测定尿液、唾液、血液或头发中的苯甲酰爱康宁，用于临床毒理学、尿液药物测试、疼痛处方监测或法医分析。苯甲酰爱康宁是可卡因的主要代谢产物，也是测定可卡因使用的一种主要生物标志物。
应用
- Mass Spectrometry Internal Standard: Benzoylecgonine-d₃ is utilized as a robust internal standard in mass spectrometry to enhance the accuracy and precision of quantitative analysis of cocaine metabolites in clinical toxicology studies, providing crucial data for forensic and clinical applications (Handley et al., 2019).
- Forensic Toxicology Research: The application of Benzoylecgonine-d₃ in gas chromatography-mass spectrometry (GC-MS) underscores its value in the forensic analysis of cocaine and its metabolites in biological samples, offering reliable quantification essential for legal and medical investigations (Fleming et al., 2010).
- LC-MS/MS Quantitative Analysis: Benzoylecgonine-d₃ serves as a critical component in developing validated LC-MS/MS methodologies for drug testing, ensuring the traceability and reproducibility required in doping control and therapeutic drug monitoring (Lin et al., 2001).
- Pharmacokinetic Studies: The use of stable isotope-labeled Benzoylecgonine-d₃ enables detailed pharmacokinetic studies, helping to understand the metabolism of cocaine and assess the impact of various physiological and pathological conditions on drug metabolism (Lin et al., 2001).
- Drug Metabolism Analysis: In forensic science, Benzoylecgonine-d₃ is crucial for developing sensitive and selective analytical methods for detecting and quantifying cocaine use, supporting both clinical diagnostics and legal proceedings (Hall et al., 1999).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
WGK
WGK 2
闪点(°F)
49.5 °F
闪点(°C)
9.7 °C
法规信息
胰岛素激素类产品
危险化学品
Oruc Allahverdiyev et al.
Turkish journal of medical sciences, 45(6), 1380-1389 (2016-01-19)
Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and
James Brian McAlvin et al.
Investigative ophthalmology & visual science, 56(6), 3820-3826 (2015-06-13)
Amino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with minimal adverse tissue
Yanyan Qiu et al.
Scientific reports, 4, 6605-6605 (2014-10-14)
This study examined whether a novel imidazoline I₂ receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I₂ receptor ligands. Eight male Sprague-Dawley rats were trained to discriminate 10.0 mg/kg
Kalpashri Kesavan et al.
Respiratory physiology & neurobiology, 201, 93-100 (2014-07-11)
Sedative-analgesics are often given to newborn infants and are known to affect many components of the autonomic nervous system. While morphine is most frequently used, α-2 adrenergic receptor agonists are being increasingly used in this population. Alpha-2 adrenergic receptors agonists
Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.
Paula E Park et al.
Addiction biology, 20(2), 275-284 (2013-12-18)
Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to closely interact
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