推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
SNAP-N-SPIKE®, SNAP-N-SHOOT®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
2-8°C
SMILES字符串
NC1=CC=C2C(C(C3=C(Cl)C=CC=C3)=NCC(N2)=O)=C1
InChI
1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)
InChI key
HEFRPWRJTGLSSV-UHFFFAOYSA-N
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一般描述
该认证的Snap-N-Spike®溶液，适合作为法医分析、临床毒理学和尿液药物检测的许多GC/MS或LC/MS应用中校准物或对照品中的起始材料。作为主要代谢产物，7-氨基氯硝西泮可用于监测母体药物氯硝西泮的使用。以Klonopin®和Rivotril出售的氯硝西泮是一种长效苯二氮卓类药物，具有抗焦虑、抗惊厥、肌肉松弛和催眠作用。
应用
- 7-Aminoclonazepam as a Reference Standard in Forensic Toxicology: This benzodiazepine metabolite is critical for forensic applications, where it serves as a reference standard for the confirmation and quantitation of clonazepam in biological samples. Its reliable detection in toxicological screenings is crucial for legal and medical interpretations (Elenstål et al., 2023).
- Pharmacokinetic Studies with 7-Aminoclonazepam: In pharmacokinetics, 7-Aminoclonazepam is studied to understand the metabolic pathways of clonazepam, particularly its transformation and elimination in the human body. This research is vital for developing dosing regimens that optimize therapeutic outcomes while minimizing side effects (Øiestad et al., 2023).
- Stability Studies of 7-Aminoclonazepam: Stability testing of 7-Aminoclonazepam in various storage conditions provides essential data on how storage conditions affect the integrity of this compound. Such information ensures the accuracy and reliability of bioanalytical assays used in clinical and forensic settings (Dahlin & Petrides, 2022).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Klonopin is a registered trademark of Hoffmann-La Roche Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F - closed cup
闪点(°C)
2 °C - closed cup
法规信息
监管及禁止进口产品
Marjorie Chèze et al.
Forensic science international, 145(2-3), 123-130 (2004-09-29)
The number of reports on drug facilitated crimes is increasing these last years. Apart from ethanol and cannabis, benzodiazepines (BZD) and analogs are the most common drugs reported to be used probably due to their amnesic and sedative properties. We
Albert A Elian
Forensic science international, 134(1), 54-56 (2003-07-05)
The ability of five commercially available enzyme-linked immunosorbent assay (ELISA) benzodiazepines to detect clonazepam and 7-aminoclonazepam in blood and urine was investigated. To determine the cross-reactivity of various ELISA assays, drug free blood and urine were fortified with clonazepam and
Adam Negrusz et al.
Journal of analytical toxicology, 26(7), 471-478 (2002-11-09)
The objective of this paper was to determine whether benzodiazepine clonazepam (CLO) and its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in hair collected from healthy volunteers after receiving a single 3-mg dose of Klonopin (clonazepam). Such data would be
Adam Negrusz et al.
Analytical and bioanalytical chemistry, 376(8), 1198-1204 (2003-07-08)
The objective of this paper was to determine how long after administration of benzodiazepine clonazepam (CLO), its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in urine collected from 10 healthy volunteers who received a single 3-mg dose of Klonopin (clonazepam).
I Petters et al.
Journal of chromatography, 306, 241-248 (1984-03-09)
A high-performance liquid chromatographic method is reported for the determination of clonazepam and its metabolites 7-amino- and 7-acetamidoclonazepam. Extraction from buffered plasma is carried out at pH 9.5 with hexane-ethyl acetate (7:3) for clonazepam and with chloroform for the metabolites.
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