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Merck
CN
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安全信息

A-144

Supelco

酰基肉碱混标2 (C4,iC4,C5,iC5,C6,C8,C10,C12,C14,C18) 溶液

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid), certified reference material, ampule of 1 mL, Cerilliant®

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别名:
Acylcarnitines Mix 2 Solution
经验公式（希尔记法）:
C25H49NO4
分子量:
427.66
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

组成

Butyryl-L-carnitine, 100 μg/mL
Decanoyl-L-carnitine, 100 μg/mL
Hexanoyl-L-carnitine, 100 μg/mL
Isobutyryl-L-carnitine, 100 μg/mL
Isovaleryl-L-carnitine, 100 μg/mL
Lauroyl-L-carnitine, 100 μg/mL
Myristoyl-L-carnitine, 100 μg/mL
Octanoyl-L-carnitine, 100 μg/mL
Stearoyl-L-carnitine, 200 μg/mL
Valeryl-L-carnitine, 100 μg/mL

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid)

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

格式

multi-component solution

储存温度

−70°C

相关类别

一般描述

A Certified Spiking Solution® of routinely tested Butyryl-L-Carnitine, Isobutyryl-L-Carnitine, Valeryl-L-Carnitine, Isovaleryl-L-Carnitine, Hexanoyl-L-Carnitine, Octanoyl-L-Carnitine, Decanoyl-L-Carnitine, Lauroyl-L-Carnitine, Myristoyl-L-Carnitine and Stearoyl-L-Carnitine at concentrations of 100-200 μg/mL. Acylcarnitines are biomarker for many inborn errors of metabolism that cause several metabolic diseases and are routinely tested in newborn screening programs. This multi-component mix is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls, calibrators, and linearity standards for LC-MS/MS assays; as system tuning/suitability standards; linearity verification; and internal proficiency testing. The stable, quantitative solution format provides significant benefits to the user such as convenience of use, material savings, and increased efficiency of labor. Certified concentration values for each component provides increased efficiency from less time remaking pools due to dilution errors or rerunning samples.

应用


  • Metabolic Disorder Biomarker Development: Acylcarnitines are crucial in diagnosing very long-chain acyl-CoA dehydrogenase deficiency. This research utilizes acylcarnitine profiles to improve understanding and treatment approaches for metabolic disorders, employing mass spectrometry metabolites for precise analysis (Bleeker JC et al., 2020).

  • High-Purity Acylcarnitine Standards in Research: The study demonstrate the simultaneous extraction of metabolomes and lipidomes, including acylcarnitines, using ultra-high performance liquid chromatography/mass spectrometry. This methodology supports high-precision studies in fatty acid oxidation and metabolic assay development (Chen S et al., 2013).

  • Application in Inborn Errors of Metabolism Assay: The research investigates how dietary bioactive polyphenols affect the mitochondrial carnitine acylcarnitine carrier, showcasing the utility of acylcarnitines in studying the impact of natural compounds on metabolic pathways, vital for understanding inborn errors of metabolism (Console L et al., 2019).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

危险化学品

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Analysis of Acylcarnitines in Dried Blood Spots (DBS) Samples by FIA-MS/MS

In this article we provide a complete workflow of quantification and identification of acylcarnitines in dried blood spots (DBS) using stable isotope-labeled (SIL) acylcarnitines CRMs by FIA-MS/MS.

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