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表单
powder
制造商/商品名称
Avanti Research™ - A Croda Brand LM1902
包装
1 ea of 1 × (with stopper and crimp cap (LM1902-1EA))
应用
lipidomics
metabolomics
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
InChI
1S/C46H82O16P2.2H3N/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)60-38(36-58-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-59-64(56,57)62-46-43(51)41(49)42(50)45(44(46)52)61-63(53,54)55;;/h11,13,17,19,21,23,27,29,38,41-46,49-52H,3-10,
InChI key
IOJKXWHTFCVKEI-QBMVDDEMSA-N
一般描述
Phosphatidylinositol 5-Phosphate (PI5P) is present in the endosomes, trans-Golgi network and smooth endoplasmic reticulum. It is abundantly localized to the plasma membrane but also found in the intracellular membranes of the organelles.
生化/生理作用
Phosphorylation of phosphatidylinositol 5-phosphate (PI5P) by phosphatidylinositol 5-phosphate (PI5P) type II PIPKs (PIPKIIs) produces phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2), which, is a potent signaling molecule. PI5P is a lipid messenger associated with stress-induced pathways in the nucleus. It is known to possess housekeeping functions and aids in cell activation during bacterial infections.
包装
2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1902-1EA)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Amber J McCartney et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 36(1), 52-64 (2013-12-11)
Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol
Matthew W Bunce et al.
The Journal of biological chemistry, 283(13), 8678-8686 (2008-01-26)
Phosphoinositide signaling pathways regulate numerous processes in eukaryotic cells, including migration, proliferation, and survival. The regulatory lipid phosphatidylinositol 4,5-bisphosphate is synthesized by two distinct classes of phosphatidylinositol phosphate kinases (PIPKs), the type I and II PIPKs. Although numerous physiological functions
Natsuko Jin et al.
Biochemical Society transactions, 44(1), 177-184 (2016-02-11)
Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. The low-abundance signalling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is critical for cellular homoeostasis and adaptation to stimuli. A large complex of proteins that includes the lipid kinase Fab1-PIKfyve
Julien Viaud et al.
Nature communications, 5, 4080-4080 (2014-06-07)
PtdIns5P is a lipid messenger acting as a stress-response mediator in the nucleus, and known to maintain cell activation through traffic alterations upon bacterial infection. Here, we show that PtdIns5P regulates actin dynamics and invasion via recruitment and activation of
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