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方案
>99% (TLC)
表单
ethanol solution
包装
pkg of 1 × 1 mL (900128E-100UG)
pkg of 1 × 1 mL (900128E-500UG)
制造商/商品名称
Avanti Research™ - A Croda Brand
浓度
100 μg/mL in ethanol (900128E-100UG)
500 μg/mL in ethanol (900128E-500UG)
运输
dry ice
储存温度
−70°C
SMILES字符串
O[C@@H](CCCCC)\C=C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI
1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
InChI key
JSFATNQSLKRBCI-VAEKSGALSA-N
一般描述
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
生化/生理作用
15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.
包装
2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
55.4 °F
闪点(°C)
13 °C
法规信息
危险化学品
15 (S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis
Profita M, et al.
American Journal of Physiology. Cell Physiology, 279(4), C1249-C1258 (2000)
Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of
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