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表单
powder
包装
pkg of 1 × 1 mg (900115P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 900115P
运输
dry ice
储存温度
−20°C
SMILES字符串
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
InChI
1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18?/m0/s1
InChI key
BGKHCLZFGPIKKU-BGEXMHJYSA-N
一般描述
Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).
Prostaglandins (PG) are hormones present in many tissues and organs. They are long chain polyunsaturated fatty acids. PGA1 is a cyclopentenone molecule.
应用
Prostaglandin A1(PGA1) has been used to activate Ca2+ channel of human sperm (CatSper).
生化/生理作用
Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients.
Prostaglandins (PG) mediates various physiological functions and the action of blood vessels. PGA1 also inhibits viral replication and promotes heat shock protein (HSP) expression, exhibiting neuroprotection. PGA1 is known to relieve cellular stress.
包装
5 mL Amber Glass Screw Cap Vial (900115P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine
Gobbetti T, et al.
PLoS ONE, 8(9), e75581-e75581 (2013)
Progesterone activates the principal Ca 2+ channel of human sperm
Lishko P, et al.
Nature, 471(7338), 387-387 (2011)
Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes
Cornelussen RNM, et al.
Journal of Molecular and Cellular Cardiology, 33(8), 1447-1454 (2001)
Induction of ferritin and heat shock proteins by prostaglandin A1 in human monocytes: Evidence for transcriptional and post-transcriptional regulation
Elia G, et al.
European Journal of Biochemistry, 264(3), 736-745 (1999)
n-3 Omega fatty acids: a review of current knowledge
Gogus U and Smith U
International Journal of Food Science and Technology, 45(3), 417-436 (2010)
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