推荐产品
形式
powder
包装
pkg of 1 × 5 mg (890893P-5mg)
制造商/商品名称
Avanti Polar Lipids
脂质类型
transfection
cationic lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C
一般描述
N4-Cholesteryl-Spermine (GL67) comprises of the cationic lipid GL67 with spermine and cholesterol.
应用
- GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.: This study explores the use of GL67 liposomes for delivering siRNA to human lung cancer cells, highlighting its potential for targeted cancer therapies (Jarallah et al., 2023).
- Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.: The research focuses on the efficacy of GL67 liposomes in aerosol form for non-viral gene therapy in the lungs, demonstrating significant gene transfer efficiency (Le Gall et al., 2021).
- Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.: The study investigates the enhancement of GL67-mediated gene transfer using low-frequency ultrasound, showing improved transfection in mouse lungs (Xenariou et al., 2010).
生化/生理作用
N4-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent.
包装
5 mL Amber Glass Screw Cap Vial (890893P-5mg)
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
In vivo imaging of gene transfer to the respiratory tract
Griesenbach U, et al.
Biomaterials, 29(10), 1533-1540 (2008)
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