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安全信息

890890C

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

别名:

1,2-二油酰基-3-三甲基铵-丙烷 (氯盐)

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About This Item

经验公式（希尔记法）:
C42H80NO4Cl
CAS号:
132172-61-3
分子量:
698.54
UNSPSC代码:
12352211
NACRES:
NA.25

形式

liquid

包装

pkg of 1 × 2.5 mL (890890C-25mg)
pkg of 2 × 20 mL (890890C-1g)
pkg of 2 × 4 mL (890890C-200mg)
pkg of 5 × 4 mL (890890C-500mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (890890C-25mg)
25 mg/mL (890890C-1g)
25 mg/mL (890890C-200mg)
25 mg/mL (890890C-500mg)

应用

advanced drug delivery

脂质类型

cationic lipids
transfection

运输

dry ice

储存温度

−20°C

SMILES字符串

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

相关类别

应用

18:1 TAP (DOTAP) 已用于制备脂质体支持的双层。

生化/生理作用

18:1 TAP (DOTAP) 为阳离子脂质结构，用于体内和体外核酸和蛋白递送。脂质组成和细胞类型会影响 DOTAP （1,2-二油酰基-3-三甲基铵-丙烷）的转染潜能。18:1 TAP（DOTAP）介导造血干细胞（HSCs）的基因敲低技术。

包装

30 mL 带螺旋盖的琥珀色窄口玻璃瓶（890890C-1g）
5 mL透明玻璃密封安瓿（890890C-200mg）
5 mL透明玻璃密封安瓿（890890C-25mg）
5 mL透明玻璃密封安瓿（890890C-500mg）

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

危险化学品
易制毒化学品（2类）

分析证书(COA)

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访问文档库

Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Wen Xiao et al.
Molecular pharmaceutics, 17(1), 229-238 (2019-11-26)
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Elias J Sayour et al.
Nano letters, 18(10), 6195-6206 (2018-09-28)
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. While
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