所有图片(2)
别名:
N1-[2-((1S)-1-[(3-氨丙基)氨基]-4-[二(3-氨基-丙基)氨基]丁基酰胺)乙基]-3,4-二[油基氧基]-苯甲酰胺
经验公式（希尔记法）:
C59H116Cl5N7O4
推荐产品
形式
powder
包装
package of 1 × 1 mg (890000P-1mg)
package of 1 × 5 mg (890000P-5MG)
制造商/商品名称
Avanti Polar Lipids 890000P
应用
advanced drug delivery
脂质类型
transfection
cationic lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCCCC/C=C\CCCCCCCCOC1=C(OCCCCCCCC/C=C\CCCCCCCC)C=C(C(NCCNC(C([NH2+]CCC[NH3+])CCC[N+](CCC[NH3+])([H])CCC[NH3+])=O)=O)C=C1.[5Cl-]
应用
MVL5已用于脂质体制备。
生化/生理作用
MVL5是阳离子脂质，是五价分子。它与脂质体制剂中的1，2-二油酰基-sn-甘油-3-乙基磷酸胆碱（DOPC）结合使用，以实现有效的基因转染。认为其毒性较小。
包装
5 mL棕色玻璃螺旋盖小瓶（890000P-1MG）
5 mL棕色玻璃螺旋盖小瓶（890000P-5MG）
5 mL棕色玻璃螺旋盖小瓶（890000P-5MG）
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Nathan F Bouxsein et al.
Biochemistry, 46(16), 4785-4792 (2007-03-30)
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene silencing. We examined cationic lipid (CL)-mediated delivery of siRNA into mammalian cells and made comparisons to CL-based DNA delivery. The effect of lipid
Cecília Leal et al.
Langmuir : the ACS journal of surfaces and colloids, 27(12), 7691-7697 (2011-05-27)
The self-assembly of a custom-synthesized pentavalent cationic lipid (MVL5) and glycerol monooleate (GMO) with small interfering RNA (siRNA) results in the formation of a double-gyroid bicontinuous inverted cubic phase with colocalized lipid/siRNA domains as shown by synchrotron X-ray scattering and
Kai Ewert et al.
Journal of medicinal chemistry, 45(23), 5023-5029 (2002-11-01)
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper describes the efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for
Chia-Ling Chan et al.
The journal of gene medicine, 16(3-4), 84-96 (2014-04-23)
Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential application in gene therapy. A key challenge in creating CL-DNA complexes for application is that their transfection efficiency (TE) is adversely affected by serum. In particular, little is known
Polyamine Drug Discovery, 226-226 (2012)
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