产品名称
PAMPA Lipid Blend I, Avanti Research™ - A Croda Brand
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 3 mL (888787D-150mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
50 mg/mL (888787D-150mg)
application(s)
microbiology
lipid type
phospholipids
shipped in
dry ice
storage temp.
−20°C
Application
The PAMPA Lipid Blend I has been used in the parallel artificial membrane permeability assay (PAMPA) for the formation of artificial membrane.
Biochem/physiol Actions
The parallel artificial membrane permeability assay (PAMPA) is useful to study the oral absorption of drugs. It helps in specifying passive transcellular diffusion.
General description
PAMPA Lipid Blend I is a lipid solution in dodecane/ethanol. Once opened, the contents of the glass ampoule should be transferred to a glass container with PTFE-lined screw cap closure for storage at -20°C. The transfer should be performed with a glass syringe or pipette. The solution should not contact plastic, i.e., do not transfer with plastic pipette tip or store in plastic vials.
Packaging
5 mL Clear Glass Sealed Ampule (888787D-150mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
supp_hazards
signalword
Danger
hcodes
Hazard Classifications
Asp. Tox. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
High-throughput artificial membrane permeability studies in early lead discovery and development
Pharmacokinetic optimization in drug research (2001)
Li Di et al.
European journal of medicinal chemistry, 38(3), 223-232 (2003-04-02)
The recent advances in high throughput screening for biological activities and combinatorial chemistry have greatly expanded the number of drug candidates. Rapid screening for BBB penetration potential early in drug discovery programs provides important information for compound selection and guidance
Fangzhou Xie et al.
Bioorganic chemistry, 92, 103273-103273 (2019-09-21)
Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of insulin signaling, is considered as a promising and validated therapeutic target for type 2 diabetes mellitus (T2DM) and obesity. Upon careful study, a series of 2-ethoxy-4-(methoxymethyl)benzamide and 2-ethoxy-5-(methoxymethyl)benzamide analogs designed
Fangzhou Xie et al.
European journal of medicinal chemistry, 164, 408-422 (2019-01-07)
Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In this work, a series of
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