形式
liquid
包装
pkg of 1 × 3 mL (888787D-150mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
浓度
50 mg/mL (888787D-150mg)
应用
microbiology
脂质类型
phospholipids
运输
dry ice
储存温度
−20°C
一般描述
PAMPA Lipid Blend I is a lipid solution in dodecane/ethanol. Once opened, the contents of the glass ampoule should be transferred to a glass container with PTFE-lined screw cap closure for storage at -20°C. The transfer should be performed with a glass syringe or pipette. The solution should not contact plastic, i.e., do not transfer with plastic pipette tip or store in plastic vials.
应用
The PAMPA Lipid Blend I has been used in the parallel artificial membrane permeability assay (PAMPA) for the formation of artificial membrane.
生化/生理作用
The parallel artificial membrane permeability assay (PAMPA) is useful to study the oral absorption of drugs. It helps in specifying passive transcellular diffusion.
包装
5 mL Clear Glass Sealed Ampule (888787D-150mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Asp. Tox. 1
补充剂危害
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Fangzhou Xie et al.
Bioorganic chemistry, 92, 103273-103273 (2019-09-21)
Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of insulin signaling, is considered as a promising and validated therapeutic target for type 2 diabetes mellitus (T2DM) and obesity. Upon careful study, a series of 2-ethoxy-4-(methoxymethyl)benzamide and 2-ethoxy-5-(methoxymethyl)benzamide analogs designed
Li Di et al.
European journal of medicinal chemistry, 38(3), 223-232 (2003-04-02)
The recent advances in high throughput screening for biological activities and combinatorial chemistry have greatly expanded the number of drug candidates. Rapid screening for BBB penetration potential early in drug discovery programs provides important information for compound selection and guidance
Fangzhou Xie et al.
European journal of medicinal chemistry, 164, 408-422 (2019-01-07)
Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In this work, a series of
High-throughput artificial membrane permeability studies in early lead discovery and development
Pharmacokinetic optimization in drug research (2001)
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