推荐产品
表单
powder
包装
pkg of 1 × 25 mg (880680P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 880680P
运输
dry ice
储存温度
−20°C
SMILES字符串
O=C(CCC(OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C
InChI key
PZQTVIDFPGJTMH-TWVCMLEGSA-N
一般描述
Ceramide is a sphingolipid metabolite. The ceramides differ in their acyl chain length.
应用
C16 PEG750 Ceramide might be used as a control to test for nonspecific interactions during titrations of DNA-nanotube complexes with polyethylene glycol (PEG)-conjugated lipids.
生化/生理作用
Therapeutic drugs enclosed in poly-ethylene glycol (PEG) conjugated ceramide serves as liposomal carriers, ensuring a longer circulation period. It exhibits a neutral surface electrostatic charge which prevents the leaking of positively charged encapsulated drug molecule.
包装
5 mL Amber Glass Screw Cap Vial (880680P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
Prakrit V Jena et al.
ACS nano, 11(11), 10689-10703 (2017-09-13)
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Michal Levy et al.
IUBMB life, 62(5), 347-356 (2010-03-12)
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common
Jamie L Betker et al.
Journal of pharmaceutical sciences (2020-02-01)
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses to PEG can promote clearance on repeat injection
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